The treatment of proaldosterone can be divided into surgical treatment and pharmacological treatment, the following drugs can be used to treat proaldosterone: 1. Spironolactone (Antiseptic): recommended first choice. Binding salt corticosteroid receptors, antagonizing aldosterone. The initial dose is 20-40 mg/day, gradually increasing to a maximum of <400 mg/day, 2-4 times/day, to maintain the blood potassium within the upper limit of normal values. It is possible to achieve blood pressure <140/90 mmHg in 48% of patients, of which 50% can be controlled by single drug. If blood pressure is not well controlled, other antihypertensive drugs such as thiazides are used in combination. The main side effects are mostly related to its binding to progesterone receptors and androgen receptors, painful male breast development, impotence, loss of libido, female menstrual disorders, etc. 2. Eplerenone: recommended for those who cannot tolerate spironolactone. Highly selective aldosterone receptor antagonist. The affinity for androgen receptors and progesterone receptors is 0.1% and 1% of spironolactone, respectively, and the incidence of sex-related side effects is significantly reduced. However, the antagonistic activity is only about 60% of that of spironolactone. 50-200 mg/d in 2 divided doses, initial dose 25 mg/d. 3. Sodium channel antagonist: Amiloride, potassium-preserving sodium-removal diuretic, initial dose 10-40 mg daily in divided oral doses, can better control blood pressure and blood potassium. There are no side effects of spironolactone. 4, calcium channel blockers: inhibit aldosterone secretion and vascular smooth muscle contraction. Such as nifedipine, amlodipine, nicardipine, etc. 5, ACEI and angiotensin receptor blockers: reduce the production of IHA aldosterone. Captopril, enalapril, etc. are commonly used. 6, glucocorticoids: recommended for glucocorticoid-inhibitable aldosteronism. Initial dose, dexamethasone 0.125-0.25 mg/d, or prednisone 2.5-5 mg/d, taken at bedtime, to maintain normal blood pressure, blood potassium and ACTH level of the minimum dose is preferred, usually less than the physiological replacement dose. Add eplerenone if blood pressure control is unsatisfactory, especially in children.