Life can not be maintained without blood, and the flow of blood can not be separated from the river that carries it – blood vessels, the whole body’s blood vessels are more than 260,000 kilometers long, equivalent to seven times the length of the equator; 24-hour blood flow length of more than 100,000 kilometers, equivalent to the Yangtze River Yellow River a year process. It can be said that any section of the blood vessels will cause damage to the human body, and many of the vascular lesions are disabling or even fatal. So it can be said that how long the life of blood vessels is, how long the life of people is. What is vascular disease? Vascular diseases can be divided into two categories in terms of the site of onset, one is diseases of the arterial system; the other is venous disease. Arterial diseases can be divided into dilated and stenotic diseases. Dilated disease such as abdominal aortic aneurysm, hepatic aneurysm, splenic aneurysm superior mesenteric aneurysm, etc. Stenosis diseases such as coronary artery disease, carotid artery stenosis and vertebral basilar artery stenosis. Venous disease can be subdivided into dilated and stenotic disease. Dilated disease such as varicose veins of the lower extremities, dilated jugular veins, and varicose veins of the gastroesophagus. Stenosis diseases such as Buga syndrome, lower extremity deep vein thrombosis, superior vena cava syndrome, etc. According to the latest findings of the World Health Organization: the incidence of vascular diseases is on the rise all over the world. The fastest increase is in developing countries where the diet and living habits are gradually westernized. In China, the incidence of vascular disease is increasing year by year as the economic level improves and the lifestyle becomes closer to that of western countries. Therefore, it is necessary for the people to consciously change their bad habits, to prevent problems before they occur, and to embark on a healthy lifestyle. It makes sense for anyone to know the causes of vascular disease. So what exactly are the factors that lead to the occurrence of vascular disease? Six high refers to high blood pressure, high blood fat, high blood sugar, high infection, high uric acid, high viscosity 1, high blood pressure: it is well known that the blood vessel wall is in the form of an elastic lumen, figuratively speaking, like a rubber water pipe. The blood flows in such a rubber tube, and the pressure of the blood acts on the blood vessel wall all the time. Life experience tells us that if the pressure of water flowing through the rubber tube increases, the rubber tube will expand; similarly, when the pressure of blood increases, the pressure on the blood vessel wall also increases, and when the elasticity of the vessel wall is not enough to overcome this pressure, the vessel wall will also slowly expand, which may eventually form a hemangioma. At the same time, in some special parts of the blood vessels, such as the bifurcation of the carotid artery, due to the influence of fluid dynamics, the blood changes from laminar flow to turbulent flow, and the shear force causes damage to the intima, and the damaged intima is prone to the formation of sterile inflammation and lipid deposition. These pathological changes gradually lead to a smaller inner diameter of the blood vessels, forming a narrowing of the blood vessels, if the diameter of the blood vessels is less than half of the original, often resulting in ischemia of the dominant organs, the most typical is angina pectoris caused by coronary artery stenosis. 2, hyperlipidemia: the human body’s internal environment is a very delicate regulatory system, if it works properly, it can adjust the various components within the blood so that they are not too high or too low and remain within a dynamic balance. But once with the dysregulation of the regulatory system, and at the same time when the lipid intake is too high, the concentration of lipids within the blood will rise. The elevated lipids gradually accumulate in the walls of blood vessels, and this accumulation eventually leads to the deposition of lipid plaques on the walls of blood vessels. The normal blood vessels of the body obtain their nutrients by drawing oxygen and nutrients from the blood flowing through the vessel walls. After lipid deposition, the lipid plaque will act like a septum to prevent the absorption of nutrients and oxygen, causing the arterial wall to be undersupplied and progressively atrophied; at the same time, inflammatory cells will migrate to the local area, and the inflammatory response will lead to the weakness of the local structure. The weakness of the arterial wall is then insufficient to resist the pressure of the blood. In the case of increased blood pressure, the weak vessel wall will, over time, become atheromatous under the impact of high pressure blood flow. At the same time, just as high blood pressure can lead to dilatation or narrowing of blood vessels, lipid deposits on the arterial wall, if because of some other related factors changes, the arterial wall does not occur dilatation, the thickness of the vessel wall increases, but leads to a reduction in the internal diameter of the blood vessels, the result is the formation of stenosis. 3, high blood sugar: diabetic patients often have much higher blood sugar than normal people, and high concentrations of blood sugar act on the walls of the blood vessels at all times. To use an analogy, the blood vessels of people at this time are like soaking in sugar water. High blood sugar and lipid deposits act together with the blood vessel wall, leading to lesions in the vessel wall. High blood sugar is often caused by low insulin levels in the body, and low insulin affects the removal of lipid deposits by the blood vessel wall itself, accelerating the onset and development of atherosclerosis. Sclerosis, lipid deposition of the vessel wall under the impact of high-pressure blood flow, very easy to occur a variety of vascular lesions, diabetic patients are particularly good ophthalmic artery, renal artery, coronary artery and other lesions. 4, high infection: Although the blood vessels are tightly wrapped by the tissue, but do not think that the vascular wall will not be infected, once the vascular wall infection, the results are often much more serious than the infection of the surface tissue. Infections affecting the blood vessels than there are generally three kinds of infection: bacteria, fungi, spirochetes, while viral infections are relatively rare. The three types of pathogens infect the vascular wall waiting, the action of the pathogen itself, the action of the inflammatory response, the action of inflammatory cells, and the action of cytokines on the vascular wall, ultimately leading to the weakness of the vascular wall and the formation of tumor-like dilatation of the vessel under the impact of high pressure and high velocity blood flow. More typical are fungal infection, pseudoaneurysm caused by bacterial infection, and syphilitic arteritis caused by syphilis. 5. High uric acid: After the uric acid in the blood exceeds the normal level, the balance in the body is disrupted and the excretory system is unable to excrete all the uric acid. So a large amount of uric acid starts to be deposited on the blood vessel wall. After the uric acid crystals are deposited locally, it causes the accumulation of a large number of inflammatory cells and forms a sterile inflammatory reaction locally. While absorbing uric acid, it also destroys the blood vessel wall, causing the weakness of the blood vessel wall, and under the impact of blood flow, the same tumor-like dilatation will be formed. 6, high viscosity: when the content of certain components in the blood increases, such as blood lipids and blood sugar, the viscosity of the blood flow will rise. Obviously, this causes an increase in friction when blood flows through the vessel wall and an increase in local shear and stress, resulting in continuous damage to the vessel lining. The intima is the most important factor in keeping the blood vessels smooth and blood flowing smoothly. After the destruction of the intima, inflammatory reaction is formed in the intima and harmful substances are deposited, which eventually leads to the thickening of the intima, the reduction of the inner diameter of blood vessels and the narrowing of blood vessels. A less: is the lack of exercise, life lies in exercise. Proper exercise helps reduce work stress, lower blood sugar, lower blood pressure, lower blood viscosity, and adjust metabolism. Naturally, the lack of exercise loses this layer of protection. At the same time obesity will make blood pressure, blood sugar, viscosity more difficult to control, lack of exercise is relatively easy to gain weight. San Lao: All these factors combined lead to the increasing incidence of vascular disease. These factors are particularly concentrated in three groups of people in our life, we call them the three old people – bosses, old cadres and old intellectuals. These people are most likely to suffer from six highs because of the special nature of their lives and work. And they are also most likely to lack exercise because they are all busy at work. This causes them to have the highest chances of suffering from vascular disease. However, this does not mean that the possibility of suffering from vascular disease is very small in our non-senior group, modern society is increasingly competitive and the pace of life is increasing. Many people’s physiological age is much older than their actual age, and white-collar workers in metropolitan areas are typical, most of them are in a subhealthy state, and the incidence of vascular disease is increasing as it is in the three old people. A thousand miles of dike is broken by an anthill. Prevention is the best way to cure the disease.