Systemic vasculitis is a group of diseases with vascular inflammation as the common pathological changes and multi-organ and multi-system involvement as the main clinical manifestations, regardless of the size of the blood vessels all show inflammatory necrotic lesions of the blood vessel wall, so this group of diseases is also known as systemic necrotizing vasculitis. Kidney is rich in vascular distribution, so it is the most common organ involved in systemic vasculitis. In addition peripheral nerves, lungs, and skin are also frequently involved. Allergic granulomatous vasculitis, also known as Churg-Strauss syndrome, is a group of systemic necrotizing vasculitis of unknown cause that primarily involves small and medium-sized arteries. It is often associated with asthma or allergic rhinitis and primarily involves the lungs, heart, kidneys, skin, and peripheral nerves. It can be found at all ages and is slightly more common in males. The general prognosis is good, but the prognosis is poor for those who invade important organs and those who have delayed treatment. Diagnostic criteria: 1. Asthma. History of asthma or diffuse high-pitched woven grass during whistling! 2, Eosinophilia greater than 10% of the classified leukocyte count. 3, Mononeuropathy or polyneuropathy: mononeuropathy due to systemic vasculitis, multiple mononeuropathy or polyneuropathy (i.e., glove/glove-like distribution.) 4, Non-fixed intrapulmonary infiltrates on radiographs appearing as migrating or transient pulmonary infiltrates due to systemic vasculitis. 5, Paranasal sinus lesions with a history of acute or chronic paranasal sinus pain or tenderness Paranasal sinuses are ambiguous on radiographs. 6.Extravascular eosinophilic infiltration: pathology shows eosinophilic infiltration in the periphery of arteries, microarterioles, and microvessels. The diagnosis can be made if 4 or more of the above 6 criteria are present.