Cancer is not only one of the major diseases that seriously threaten people’s lives, but also an important factor to produce pain, especially for patients with advanced cancer, the incidence of pain is as high as 80%. Therefore, in treating cancer pain patients, the first thing is to relieve patients’ pain, improve patients’ quality of life, restore patients’ mental state, make patients full of confidence, cooperate with doctors’ treatment, and achieve the purpose of prolonging patients’ lives. There are mainly the following methods. 1.Triple-step therapy of traditional drugs The World Health Organization (WHO) Cancer Committee formulated a drug selection program for cancer pain in 1986, namely the triple-step therapy of analgesic drugs. It can relieve cancer pain of about 70%~90% of patients. 1. First-step therapy: For patients with mild or mild to moderate cancer pain, non-steroidal anti-inflammatory analgesics are used first. The representative drugs include aspirin, paracetamol, fotarine and new long-acting analgesics such as capsaicin. In the specific treatment, the drug type should be constantly changed to reduce the adverse reactions and complications of drugs. 2.Second-step therapy: Patients with moderate or moderately severe cancer pain, who cannot tolerate the first-step therapy, can add Valium adjuvant or weak narcotics, i.e. weak opioids, such as tramadol, codeine, dextropropoxyphene, etc., on top of the original treatment. 3.Third-step therapy: Patients with severe cancer pain or patients whose second-step treatment is ineffective can switch to strong opioids, such as morphine, dihydroetorphine hydrochloride, pethidine, etc., or supplement non-opioid analgesics on top of opioids. In addition, Mescaline, OxyContin and Doregis have strong analgesia and long-lasting effects. At present, many clinicians give one of these three drugs when the patient complains of pain for the first time, but they do not know that these drugs need to be titrated to achieve good analgesia on the one hand and avoid side effects on the other, and some patients do not need strong morphine-like drugs at this time, so it is recommended that patients seek help from a qualified pain physician. 2.Cooperate with psychological and physical therapy on the basis of radiotherapy and chemotherapy The pain of cancer patients is not only the pain of the primary part of the tumor, but mostly caused by the tumor invading the bone and god soft tissues. For those cancer patients who are sensitive to radiotherapy, radiation therapy can be adopted, which has good effect on pain relief, especially for patients with bone metastases causing persistent bone pain. Patients with cancer that are not sensitive to radiotherapy can generally consider chemotherapy, which can relieve or eliminate cancer pain by destroying or shrinking cancer tumors. The pain that has not been completely relieved after radiotherapy and chemotherapy can sometimes be considered for psychological and physical therapy. While not telling the patient’s condition, talking with him more to distract his attention, together with skin stimulation, acupuncture and TENS therapy, can achieve the purpose of improving pain threshold and relieving pain. At present, electrical stimulation of spinal cord can effectively reduce the pain of cancer patients. 3.Nerve block and nerve injury therapy Nerve block therapy is the application of anesthesia technology, through local anesthetic drugs and other therapeutic drugs or nerve relaxants to perform nerve block to control cancer pain. There are mainly the following methods. Paravertebral nerve block: It is also divided into thoracic and lumbar paravertebral block. Thoracic paravertebral block is limited to patients whose pleura or chest wall is infiltrated by cancer on one side, and some patients with unilateral upper abdominal cancer pain can also use this method; after successful paravertebral puncture, inject nerve blocking drugs or connect PCA device. Lumbar paravertebral block is suitable for patients with cancer pain on one side of the lower extremity, and it can also be used to inject only nerve blocking drugs or to attach PCA devices. 2.Sympathetic ganglion block: mainly refers to stellate ganglion, thoracic sympathetic ganglion and lumbar sympathetic ganglion block. Choose various methods according to the location of cancer pain, and pay attention to accurate positioning during operation. 3.Abdominal plexus block: It is suitable for patients with cancer pain with diffuse infiltration in abdominal cavity or extensive metastasis in abdominal cavity, which is one of the most effective methods for treating severe abdominal cancer pain, but it is difficult to operate, especially it is dangerous to blindly enter the needle from the back way. If the cancer is found to have metastasized extensively during the operation and cannot be removed, then a ganglion block can be performed on the operating table in the bright view of the anterior approach to relieve the patient’s cancer pain. 4.Intra-vertebral nerve block therapy: there are two kinds of nerve blocks, epidural cavity and subarachnoid cavity, the latter is more disturbing to the whole body, and most of them use epidural cavity block. According to the site of cancer pain, the puncture point of the corresponding site is selected and the catheter is placed, and various pain-relieving drugs can be injected in stages or the PCA device can be pressed on. Nerve damaging treatment is a kind of nerve destructive treatment, which should be considered only when other palliative therapies or pharmacological therapies do not work, or when long-term application of opioids has developed drug resistance, and the consent of the patient’s family is sought. The operation is the same as nerve block, but the requirements are more stringent. Before drug injection, one must be sure that the nerve at the puncture site is the area that governs cancer pain. If there are important blood vessels and nerves passing around the puncture site, this treatment is not recommended, such as stellate ganglion. The main drugs used are phenol glycerin, ethanol, and carbolic acid.