For colchicine, the principle of taking small doses is currently recommended, i.e. 0.5mg per dose, 1 to 2 times a day for gout patients. Colchicine is one of the commonly used therapeutic drugs for gout, both during the acute attack of gout and to prevent recurrent attacks of acute gout. However, colchicine also has certain adverse reactions, among which the incidence of gastrointestinal adverse reactions is high. In addition, colchicine also has adverse effects such as inhibiting the hematopoietic function of bone marrow and causing damage to liver and kidney functions. The traditional method of taking colchicine requires patients to take larger doses in a short period of time, which can easily lead to adverse reactions in the digestive tract, and many patients can hardly tolerate it and have to stop taking it. In addition, many gout patients are older, combined with a variety of chronic diseases, liver and kidney dysfunction, the traditional colchicine dosing method increases the chance of adverse drug reactions in the elderly gout population, and even the risk of drug accumulation poisoning. Therefore, the principle of taking small doses is currently used. However, it should be noted that for patients with acute attacks of gout, if they are not allergic to colchicine and there are no contraindications to its use, it should be taken as early as possible (usually within 24 hours), otherwise it will affect the efficacy of the drug. Therefore, colchicine is one of the commonly used therapeutic drugs for gout, and the principle of taking it as early as possible and in small doses is currently recommended, and patients should fully consult their rheumatologists before using it, rather than taking it at their own discretion.