There are many causes of dyspnea in the middle of the night, mainly caused by diseases related to the respiratory and cardiovascular systems. Patients with bronchial asthma tend to have acute attacks in the evening, and some patients with major asthma attacks in the evening can present with clinical manifestations of dyspnea. In addition, patients with heart failure in cardiovascular disease tend to have dyspnea at night because they sleep in a flat position at night, and the degree of pulmonary stasis is increased, and they can develop evening cardiogenic asthma with forced sitting up and telescopic breathing. Some patients with severe sleep apnea syndrome also have symptoms of dyspnea due to apnea and hypoventilation and self-perceived dyspnea. Some patients with anxiety and hysteria also need to be identified at this time when they sleep at night with discomfort such as self-perceived dyspnea and dyspnea. Therefore, patients with dyspnea in the middle of the night must be treated accordingly according to the cause.