Patient: Description (onset, main symptoms, hospital, etc.): 30 years old, married, with a child of more than 1 year old. In June this year, I had a physical examination and was told that I had severe cervical erosion. The results of the YCT cytology examination were: atypical squamous epithelium with no clear diagnostic significance was seen. White blood test: WBC+++ . Then I had a colposcopy done by an acquaintance who didn’t give me a report card and told me that it looked very unlikely to be cancerous and that the erosion was extensive but shallow. Then a biopsy was done. When the sample was taken, the doctor told me that the specimen was well obtained and the report was: CIN grade 2 with glandular involvement and then the HPV test was negative. After a series of tests, some doctors told me that I needed to undergo a cervical conization, saying that it was scary, while others told me that LEEP would be fine. I was under a lot of psychological pressure and didn’t know what to do. Can this disease be handled at a county hospital? Do I need to go to a big hospital to find a doctor to do the surgery? I would like to ask you to give me your treatment advice, thank you very much! Zhao Xiaofeng: Your case is not too serious overall, but there are several problems. The first is that you should have cervical or vaginal inflammation, which should be treated first. The second is that you need a more standardized and complete colposcopic evaluation to basically clarify the distribution and extent of the lesion. The third is whether a 3, 6, 9, or 12 point biopsy is the most appropriate in the context of an adequate colposcopic evaluation and whether sampling of the cervical canal is needed. Regarding the surgery, whether it is cold knife conization or LEEP, in general it is not a very big surgery and many doctors are able to do it. The key is to find a doctor who is skilled in this area of surgery to do this surgery, and then to review it strictly and regularly after the surgery. Your condition has been understood and I suggest you refer to my article “CINII-III Involved Glands, Cold Knife Conization or LEEP”. Patient: I really appreciate Dr. Zhao’s patient answer, which made me feel much more at ease and put my mind at ease. Thank you very much! Patient: Hello, Dr. Zhao, I’m here again. I had a LEEP procedure at the county hospital two days ago, and today the hospital called to tell me the very bad news that the histopathological examination of the cervical margin was CIN3 with involvement of glands. I don’t know how to describe how I feel now. I’m still so young, and if I have my uterus removed, I don’t want to become a woman without a uterus from now on. What should I do? Patient: Also, why is this happening to me even though I am HPV negative? Is it a problem with the innate cancer suppressor gene? Zhao Xiaofeng: The treatment principles for CIN2 and CIN3 are the same. If LEEP is done properly, hysterectomy is usually not necessary. There are many testing methods, some of which may not always have a high sensitivity, and there are certainly HPV-negative CINs.