What should I do if I have elevated blood uric acid in combination with hypertension?

  Patients with hypertension often have higher than normal blood uric acid levels. At present, there are about 120 million people with hyperuricemia in China, which has a similar epidemic trend with hypertension, diabetes and hyperlipidemia. According to statistics, about 25% of untreated hypertensive patients have hyperuricemia. About 40-50% of hypertensive patients treated with diuretics are also associated with hyperuricemia. When hyperuricemia and hypertension coexist, patients tend to have a three- to five-fold higher incidence of cardiovascular disease, such as coronary heart disease, than hypertensive patients with normal blood uric acid levels. Like blood pressure, a person’s blood uric acid level tends to increase with age, and changes are influenced by a variety of factors such as genetics, diet, weight, gender, race and lifestyle.  There are two main sources of uric acid in the body: a small proportion is produced from the breakdown of nucleoprotein-rich foods, and a large proportion is produced from the synthesis of amino acids, ribose phosphate, other small molecules and the metabolism of nucleic acids. Two-thirds of the body’s uric acid is excreted through the urinary tract, and one-third is excreted by the intestine or broken down by bacteria in the gut.  Hyperuricemia is a metabolic disease caused by a long-term disorder of purine metabolism. Its occurrence is mainly related to the increase of uric acid production or decrease of uric acid excretion. Research shows that when the blood uric acid exceeds 310mmol/L, it is a high level of uric acid blood, but at this time the patient will not necessarily appear obvious clinical symptoms, once the hyperuricemia lasts longer, or when the blood uric acid exceeds 410mmol/L, it is easy to produce uric acid crystals attached to the joints or kidneys, the patient will appear gouty arthritis or gouty kidney disease. Hyperuricemia and hypertension are closely related to each other and are independent risk factors for the development of coronary heart disease.  With the increasing understanding of the correlation between hyperuricemia and the development of hypertension, it is realized that it is of positive significance to carry out uric acid-lowering treatment in the process of lowering blood pressure. For hypertension combined with hyperuricemia, attention must be paid to the blood uric acid level while lowering blood pressure, especially when diuretics are used in combination, and when necessary, drugs that both lower blood pressure and uric acid can be used. Chinese medicine believes that hyperuricemia has a pathological basis of phlegm and blood stasis, so it is treated by combining phlegm and blood circulation with pharmacological research on Chinese herbs that have the effect of lowering uric acid and diet and exercise.