Melatonin is generally an amine hormone secreted by the human, or mammalian, pineal gland, whose primary effect is to reduce intracellular melanin under dark conditions, thereby affecting the color of an individual’s skin. Physiological amounts of melatonin are essential hormones that have a positive effect on physiological regulation and are generally not detrimental to liver function. However, if a patient ingests it exogenously, such as orally or by other means, it can affect liver function. Because most of the substances are detoxified and metabolized by the liver, there is a risk of increasing the burden on the patient’s liver in the process. Especially in patients with underlying liver disease, such as viral hepatitis, where liver function is generally poor, excessive use of melatonin can cause hepatocyte necrosis and liver insufficiency. The liver function of glutamic aminotransferase and glutamic oxalacetic aminotransferase is elevated, when the patient should consider further treatment according to the degree of elevation.
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