Osteoporosis caused by tuberculosis should first be treated with anti-tuberculosis therapy, and then osteoporosis should be treated secondly. If osteoporosis is caused by tuberculosis, the first goal is to control the tuberculosis and treat the disease from the root. Specialized anti-tuberculosis drugs, such as isoniazid, are used to control tuberculosis that is in the active stage, so that it gradually loses its activity, in order to avoid the further development of osteoporosis. Secondly, targeted treatment of osteoporosis is adopted, such as the use of calcium agents such as calcium citrate, drugs to inhibit bone resorption such as Ecocalcitonin, drugs to inhibit osteoclasts ammonium lisdephosphate, etc. However, if accompanied by vertebral compression fracture, bone compression of the nerve root and other conditions may need to be combined with surgical treatment, the details of which are based on the doctor’s instructions.