High Intensity Focused Ultrasound Knife (HIFU) is a kind of local non-invasive treatment for tumor, which does not have the damage of radiation, chemotherapy drugs and embolic agents to liver tissues. In addition, high-energy ultrasonic waves in the treatment area produce instantaneous cavitation effect, which causes transient compression and expansion of the membrane structure of cells in the target area until collapse, resulting in irreversible damage such as loss of continuity of the membrane structure of cells and rupture of organelles, thus achieving the purpose of tumor treatment, which is an important supplement to surgery, chemotherapy, TACE and other treatment methods. It is an important complementary technology to surgery, chemotherapy, TACE and other treatment methods. Ma Cunkai, Department of Interventional Medicine, Affiliated Hospital of Qinghai University