Guilin Li, Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China This is a case of bone anomalous proliferation syndrome combined with pituitary growth hormone adenoma, and in the past, it was not possible to take transsphenoidal surgery to treat pituitary adenoma. At present, with the assistance of neuronavigation, we have been able to abrade the proliferating bone at the base of the skull and resect the pituitary adenoma.