Recently, I encountered 2 patients in my clinical work, and the final diagnosis was cholangiocarcinoma. Cholangiocarcinoma is very rare in clinical practice, but you can actually see it if you are willing. One of the cases was a post-cholecystectomy patient who developed jaundice and cystic material in the liver with infection after surgery, and repeated suctioning revealed that the extracted material was bile. After the consultation, it was found that the patient’s right hepatic artery was cut off, which might be related to the surgery, and the right hepatic artery was not supplied with blood, so the right hemiliver showed damage to the biliary system, the dilatation of the intrahepatic bile ducts, the obstruction of bile excretion, and bile collection in the liver, which was combined with the infection, and the endoscopic insertion of the plastic stent was ineffective, and it was quickly improved with a change of the nasobiliary tube. Another patient had a spontaneous cholangioma, which is very rare, caused by a choledochal stone that resulted in a subperitoneal fluid collection, and the aspirate was bile-like, which improved after ERCP treatment. A cholangioma is a collection of bile outside the bile ducts. It is rare in clinical practice, but when the effusion is bile-like and there is damage to the right half of the liver, one should always ask why. The diagnosis of these 2 cases has significantly helped us to improve our clinical level.