Nasopharyngeal carcinoma refers to squamous cell tumors that occur in the mucosal epithelium of the nasopharynx, and is more prevalent in southern China, such as Guangdong, Guangxi, Hunan and other provinces, especially in the central and western regions of Guangdong, hence the name “Guangdong tumor”. The cause of nasopharyngeal carcinoma is not yet clear, but it is believed that its occurrence is mainly related to EBV infection. The main symptoms of most patients include blood in the sputum after nasal aspiration, nose blockage, tinnitus, hearing loss, occlusion in the ear, headache, double vision (diplopia), numbness of the facial skin, etc. About 70% of patients will find a neck mass (enlarged lymph nodes), while a smaller number of patients will have symptoms such as tongue muscle atrophy and tongue extension, drooping eye risk and eye fixation. The diagnosis of nasopharyngeal cancer requires electronic fiberoptic nasopharyngoscopy to obtain pathology of nasopharyngeal lesions to confirm the diagnosis, followed by cervical lymph node aspiration or biopsy and serum EBV can assist in the diagnosis. After the diagnosis of the disease is confirmed, a comprehensive examination should be performed to clarify the stage. MRI enhancement of the nasopharynx and neck is a must, because MRI shows the extent of invasion of the nasopharyngeal lesions more clearly than CT, and identifies the target area for radiotherapy. If MRI cannot be done for some reasons, CT enhancement should be chosen. Other items include CT scan of the chest, abdominal ultrasound and bone ECT or whole body PET examination to understand whether the tumor has invasion of other parts. Because of the depth of nasopharyngeal cancer and local infiltration of tumor into adjacent structures, it is difficult to be removed completely by surgery, and the tumor is sensitive to radiotherapy, so radiotherapy has been the main treatment method for nasopharyngeal cancer. Radiotherapy techniques include conventional radiotherapy and intensity-modulated radiotherapy (IMRT), while intensity-modulated radiotherapy can not only improve patients’ treatment effect but also protect patients’ normal organ functions and improve patients’ long-term survival quality of life compared with conventional radiotherapy. Therefore, we mainly use intensity-modulated radiation therapy technique for the treatment of nasopharyngeal cancer, and radiotherapy is done 5 times a week (Monday to Friday), and the total course of treatment is usually about 7 weeks. Since some patients lose a lot of weight during radiotherapy, we usually recreate the radiotherapy plan at 25 times, so as to better ensure the quality of radiotherapy. Patients with early stage nasopharyngeal cancer can be treated with radiotherapy alone, while patients with more extensive local invasion need to undergo simultaneous radiotherapy and adjuvant chemotherapy. We will do 2-3 cycles of induction chemotherapy first, and then use synchronous radiotherapy after the patient’s lesion shrinks, and some patients also need 2 cycles of adjuvant chemotherapy. If the patient’s financial resources allow, biologically targeted therapy (Epiduo or Tamsulosin) can be added to radiotherapy to further improve the efficacy. Patients will require nasopharyngeal irrigation during radiotherapy. This operation is very important because it can help to discharge necrotic secretions from the nasopharyngeal cavity after radiotherapy and reduce the occurrence of posterior nostril adhesions, and we generally recommend patients to adhere to it for at least half a year. Secondly, oral care should be paid attention to during radiotherapy. Patients are advised to brush their teeth with fluoride toothpaste and soft-bristled toothbrush, gargle with specially formulated mouthwash after meals, and use goldin peptide for topical application when ulcers appear in the mouth. In addition, skin care is also important. Patients can use prophylactic topical medication (Biafen) to apply after the start of radiotherapy, while wearing wide cotton clothes and prohibiting scrubbing, scratching and exposure to sunlight with soap and other irritating liquids. Nasopharyngeal cancer is a clinically highly curable tumor. The cure rate of early stage patients can reach 90% after standardized treatment. Therefore, once patients are diagnosed with nasopharyngeal carcinoma, they should actively cooperate with doctors to successfully complete the treatment course, so that they can obtain the ideal curative effect.