One of the principles of antipsychotic drug application, full dose and full course of treatment. That is, the choice of an antipsychotic drug, should be gradually increased to the highest dose specified in the instructions for use, the high amount of maintenance for 4-6 weeks, such as ineffective or unsatisfactory efficacy, and then switch to other drugs. And no longer use this drug in the future. Then switch to a new antipsychotic drug, and still do so, which is the standard treatment. Except for two exceptions, 1, the patient’s symptoms completely disappeared when the highest dose was not yet increased (this situation is rare), 2, in the process of increasing the dose, there are obvious side effects, and the effect is not obvious with drugs to eliminate side effects, encountered in these two cases, there is no need to use the highest dose. However, in practice, many patients (especially some patients treated in informal psychiatric hospitals) do not use the high amount of drugs that change (the amount of drugs or the use of time is not enough), the results are not effective. And this long-term irregular treatment delays the best treatment period for patients. It creates difficulties for future treatment. Before adopting a new treatment plan, the doctor must have detailed information about previous treatment, so the family should give a detailed description of previous treatment. If standardized treatment with two different types of antipsychotics has been used and still has unsatisfactory results, the psychosis is refractory. If it is not standardized treatment with poor efficacy. It is inadequate treatment.