1.Local reactions Some of the more irritating chemotherapy drugs can cause serious local reactions when injected intravenously. A. Phlebitis: It is manifested as pain and redness of the used vein site, and sometimes it can be seen as vein embolism and skin pigmentation along the vein. B, local tissue necrosis: when the irritating drugs leak into the subcutaneous can cause local tissue chemical inflammation, redness, pain and even tissue necrosis and ulceration, and does not heal over time. Bone marrow suppression Most chemotherapy drugs have different degrees of bone marrow suppression, which is often the dose-limiting toxicity of antitumor drugs. In the early stage, myelosuppression can be manifested as a decrease in white blood cells, especially total cells, and in severe cases, platelets, red blood cells and hemoglobin can be reduced. 3, gastrointestinal toxicity Most chemotherapy drugs can cause gastrointestinal reactions, manifested as dry mouth, loss of appetite, nausea, vomiting, and sometimes oral mucositis or ulcers. Constipation, paralytic intestinal obstruction, diarrhea, gastrointestinal bleeding and abdominal pain can also be seen. 4.Immunosuppression Chemotherapy drugs are generally immunosuppressive drugs, which have different degrees of inhibitory effects on the immune function of the body. The immune system of the body plays an important role in eliminating the remaining tumor cells in the body, and when the immune function is low, the tumor is not easily controlled, but accelerates the process of recurrence or metastasis. 5.Nephrotoxicity Some chemotherapy drugs can cause kidney damage, mainly manifested as acute necrosis and degeneration of renal tubular epithelial cells, interstitial edema, tubular dilatation, and renal failure in severe cases. Patients may have back pain; hematuria, edema, abnormal urine tests, etc. 6, liver damage The liver reaction caused by chemotherapy drugs can be acute and transient liver damage, including necrosis, inflammation, or due to long-term drug use. It causes chronic liver injury, such as fibrosis, steatosis, granuloma formation, eosinophil infiltration, etc. Clinical manifestations can be abnormal liver function tests, pain in the liver area, hepatomegaly, xanthogranuloma, etc. 7, cardiotoxicity Clinical may manifest as heart rate arrhythmias, heart failure, medical education|education network collection and collation of cardiomyopathy syndrome (patients show weakness, active dyspnea, episodes of nocturnal dyspnea, heart failure may have a fast pulse, rapid breathing, liver size, heart enlargement, pulmonary edema, swelling and pleural fluid, etc.), and abnormalities in the electrocardiogram. 8, pulmonary toxicity A small number of chemotherapeutic drugs can cause pulmonary toxicity, manifested as interstitial inflammation and pulmonary fibrosis. Clinical manifestations can be fever, dry cough, shortness of breath, more acute onset, accompanied by granulocytosis. 9, neurotoxicity Some chemotherapy drugs can cause peripheral neuritis, manifested as finger (toe) numbness, loss of tendon reflexes, abnormal sensation, and sometimes constipation or paralytic intestinal obstruction can occur. Some drugs can produce central neurotoxicity, mainly manifested as abnormal sensation, reduced vibration, numbness, tingling, gait disorder, ataxia, drowsiness, mental abnormalities, etc. 10, hair loss Some chemotherapy drugs can cause different degrees of hair loss, generally speaking only hair loss, sometimes other hairs can also be affected, which is the result of chemotherapy drug damage to hair follicles. The degree of hair loss is usually related to the concentration and dose of the drug. 11, other Such as hearing loss, rash, facial or skin flushing, nail deformation, osteoporosis, bladder and urethral irritation, infertility, amenorrhea, sexual dysfunction, male breast enlargement, etc. can also be caused by some chemotherapeutic drugs.