Parkinson’s disease (PD), also known as tremor palsy, is a slowly progressive movement disorder common in middle-aged and elderly people. The term “tremor palsy” was first coined in 1817 by British physician James Parkinson, and the disease has since been named after his surname. Some famous figures such as Pope John Paul II and boxing champion Ali were patients with Parkinson’s disease. Patients have degeneration of pigment cells in the substantia nigra, blue spot and dorsal nucleus of the vagus nerve, resulting in impaired production of dopamine transmitters, causing an imbalance between the dopaminergic and cholinergic systems, and causing a series of clinical manifestations. There are four main clinical symptoms of Parkinson’s disease: resting tremor, bradykinesia, tonicity and postural balance disorders. Typical patients show reduced facial expressions, called “mask face”; rhythmic tremor of the fingers, forming the so-called “pill-rubbing movement”; special posture when standing: head tilted forward, trunk bent down; walking in a panic gait that is The “mincing gait”. The latest epidemiological survey shows that the prevalence of Parkinson’s disease in China is 1.7% in people over 65 years of age, and about 1.7 million people over 55 years of age suffer from the disease. The pathogenesis of Parkinson’s disease is unknown, and due to the phenomenon of familial aggregation, certain genetic defects can cause Parkinson’s disease. The following protein genes encoding the disease are mainly reported at home and abroad: α-co-nucleoprotein, parkin, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), DJ-1, PINK1, LRRK2, ATP13A2, and Omi/HtrA2. In addition, the environmental factors such as herbicides, pesticides and other chemicals may also be responsible for triggering the disease.? Many diseases or factors can produce clinical symptoms similar to Parkinson’s disease, called Parkinson’s syndrome, of which those with a clear etiology are called secondary PD, such as PD caused by infections, drugs (dopamine receptor blockers, etc.), toxins (MPTP, carbon monoxide, manganese, etc.), vascular (multiple cerebral infarction) and head trauma, etc. In addition, some degenerative diseases of the central nervous system can also be associated with Parkinson’s disease symptoms, such as multisystem atrophy, which can manifest as simple Parkinson’s disease in the early stage of the disease, and then gradually some other symptoms of the nervous system, such as autonomic dysfunction, will appear, and their initial diagnosis will be revised. The treatment for Parkinson’s disease is mainly divided into drug therapy and surgery. With reasonable individualized medication, the disease can be in remission for 10-15 years or longer. Drug therapy should follow the following principles: start with small doses, gradually increase the amount of medication, “fine water flow, do not seek full effect”, and should not blindly increase the medication or stop it suddenly. In terms of drug selection, non-ergot dopamine agonists and monoamine oxidase B inhibitors are preferred in patients aged 65 years without hypoesthesia, and compound levodopa can be added if the effect is not good; compound levodopa is preferred in patients aged ≥65 years or with hypoesthesia, and dopamine agonists, monoamine oxidase B inhibitors and catechol-oxygenase-methyltransferase inhibitors are added if necessary. Concomitant intake of levodopa preparations with protein should be avoided. Surgical treatment is indicated for patients who have shown early efficacy with medication and significantly diminished efficacy with long-term treatment, along with the development of allodynia. Patients undergoing surgery must be in good general health, under 70 years of age, in good mental condition (no cognitive impairment), and Parkinson’s superposition syndrome is a contraindication to surgery. At the same time, the understanding and attention of the family and community is important to slow down the progression of the disease. It is important to highlight that not all patients with tremor have Parkinson’s disease. Idiopathic tremor, also known as primary tremor and benign tremor, is one of the most common adult tremor disorders that does not reduce the patient’s life expectancy. It is a movement disorder in which tremor is the only manifestation, mainly in the form of motor and postural tremor of the hands or head, which is aggravated by mental stress and is not accompanied by muscle rigidity or slowing of movement. The clinical diagnosis of this disease is not high due to its lack of awareness. On the other hand, some middle-aged and elderly people with idiopathic tremor are worried that they have Parkinson’s disease, so they need to be identified by a careful examination given by a specialized physician.