High antibodies to Mycoplasma pneumoniae are considered to have mycoplasma infection, but it is important to distinguish between IgM and IgG antibodies. If IgM antibodies are significantly higher than normal, consider a recent mycoplasma infection, which needs to be treated with anti-mycoplasma drugs, commonly used clinically, such as azithromycin, roxithromycin, erythromycin and other macrolides. If the patient is over 18 years old, the application of respiratory quinolones, such as levofloxacin and moxifloxacin, can also be considered, which also have good efficacy. If IgG antibodies to Mycoplasma pneumoniae are higher than normal, consider a previous infection with mycoplasma and no drugs need to be applied for treatment.