It is still common to see locally advanced breast cancer in clinical practice, which presents with malignant breast lesions invading the skin and muscle, with partial ulceration and enlarged and fused axillary lymph nodes. For such patients after pathological confirmation the doctor will recommend the patient to receive neoadjuvant chemotherapy. The most basic purposes of neoadjuvant chemotherapy are: 1. To control the systemic micrometastases of breast cancer earlier and reduce the risk of systemic metastasis. 2. As part of the systemic treatment effect, improve the local control effect and reduce the size of local lesions, so as to create the conditions for smooth surgery. Even some patients can achieve complete remission of the pathology. 3.Some patients can implement breast-conserving treatment after local lesion reduction. 4. The effectiveness and sensitivity of the chemotherapy regimen can be observed through the changes of breast lesions and lymph nodes in neoadjuvant chemotherapy, which provides a very valuable basis for the adjustment of the subsequent treatment regimen. Therefore, for locally advanced breast cancer, close cooperation between doctors and patients is needed to complete at least 4 courses of neoadjuvant chemotherapy to create favorable conditions for subsequent surgery and comprehensive treatment.