The duration of amlodipine besylate tablets depends on the patient’s specific situation and cannot be generalized. Amlodipine besylate tablets are a calcium antagonist antihypertensive drug, which is a long-acting extended-release formulation. It has a long half-life of 35-48 hours, so the effect of the drug can completely cover the whole day 24 hours. Theoretically, the ideal drug concentration can be maintained at any time of the day. However, according to the pattern of fluctuations in blood pressure, patients are most effective when taken before the highest point of blood pressure fluctuations. As individual patients with hypertension vary greatly, it is recommended to take the drug orally in the morning after waking up if the patient’s blood pressure is mainly high during the day, or at noon or after dinner if the patient’s blood pressure is mainly high in the afternoon to evening or even at night. Patients with high blood pressure are advised to have a low salt and low fat diet, salt intake should not exceed 6g per day, and to pay attention to exercise, increase a certain amount of exercise and moderate weight control.