Congenital heart disease is the most common type of congenital malformation. In mild cases, there are no obvious symptoms of congenital heart disease, and they are often discovered during physical examination. In severe cases, there may be dyspnea, cyanosis and syncope after activity, and in older children, there may be growth retardation. The appearance of congenital heart disease and those things may be related to the following things: a. Pregnant women with diabetes mellitus without treatment and control of the disease can cause the risk of congenital heart disease in the fetus is 2%, if the disease is controlled and stable in early pregnancy, the risk decreases. The risk of fetal congenital heart disease is 2% if the disease is controlled and stable in early pregnancy. Third, excessive exposure to radioactive substances such as X-rays and isotopes in early pregnancy is also one of the causes of congenital heart disease. Fourth, viral infection. Five, there is a family history of congenital heart disease. Wuhan Cardiology Hospital experts also pointed out that congenital heart disease in infants is the result of the interaction of genetic and environmental factors and other complex relationships, the following factors may affect the development of the fetus and produce congenital malformations. 1, the environmental factors of fetal development: (1) infection, the first trimester of pregnancy with viral or bacterial infections, especially rubella virus, followed by coxsackie virus, the incidence of congenital heart disease is higher in babies born. (2) Other: such as lesions of the amniotic membrane, fetal compression, early gestational pre-eclampsia, maternal malnutrition, diabetes mellitus, phenylketonuria, hypercalcemia, the application of radiation and cytotoxic drugs in the early stages of pregnancy, the mother’s excessive age, etc. all have the potential to make the fetus develop congenital heart disease in infants. 2, genetic factors: congenital heart disease has a certain degree of family tendency, may be caused by parental germ cells, chromosomal aberrations. Statistics show that 5% of patients with congenital heart disease occur in the same family with the same or similar disease species, possibly due to genetic abnormalities or chromosomal aberrations. Genetic studies have concluded that most congenital heart disease is formed by the interaction of multiple genes and environmental factors. 3.Other: Some infants with congenital heart disease are more frequent in highland areas, and some congenital heart diseases have significant differences in incidence between the sexes, indicating that the altitude and sex of the place of birth are also related to the occurrence of the disease. Among the patients with congenital heart disease, the causes can be identified is very few, but strengthening the health care of pregnant women, especially in the early stages of pregnancy to actively prevent rubella, influenza and other rubella viral diseases and avoid all factors related to the onset of the disease, is of positive significance in the prevention of congenital heart disease in infants.