As the Chinese New Year approaches, it is inevitable that friends and family will gather together to celebrate with wine. Wine can also hurt the body, we should learn to drink rationally. A small amount of alcohol can be used to promote blood circulation and prevent cardiovascular diseases. However, drinking more alcohol is harmful to the body, especially damage to the liver. So how much alcohol is safer to drink? The relationship between alcohol consumption and health is influenced by many individual factors, such as age, gender, genetics, alcohol sensitivity, lifestyle and metabolic status, so no amount of alcohol is absolutely safe to drink. The limit value of moderate alcohol consumption for adults recommended by the Chinese Nutrition Society is, for men: the amount of alcohol consumed in a day should not exceed 25g, which is approximately equivalent to 750ml of beer, or 250ml of wine, or 75g of 38° white wine, or 50g of high white wine; for women: the amount of alcohol consumed in a day should not exceed 15g, which is approximately equivalent to 450ml of beer, or 150ml of wine, or 50g of 38° white wine. Ge Guohong, Department of Hepatology, Zhenjiang Third People’s Hospital A small amount of alcohol is suitable for the majority of people, but the following groups of people must be prohibited from drinking alcohol. 1. Patients with liver disease. Because the metabolic site of alcohol in the body is mainly the liver, acetaldehyde, the metabolite of alcohol in the liver, can directly cause damage to liver cells. People with liver disease have poorer detoxification functions than the average person, drinking alcohol will aggravate liver disease. 2, patients with diabetes. Drinking alcohol will make the body’s sugar metabolism disorder, resulting in impaired pancreatic function, causing excessive glucose content in the blood, drinking alcohol is also not conducive to lipid control, increasing the burden on the liver. 3. Pregnant or breastfeeding women. Pregnant women drinking alcohol may lead to an increase in the disease of birth defects in babies; breastfeeding women who drink alcohol, alcohol will enter the baby’s body along with the milk, causing physical harm to the baby. 4, certain patients taking medication. Recently, the WeChat circle of friends rumored that taking drugs and drinking alcohol can lead to disulfiram-like reactions, which is indeed the case. The disulfiram-like reaction is a toxic reaction caused by the accumulation of acetaldehyde in the body as a result of drinking alcoholic beverages (or exposure to alcohol) after the application of drugs. It is characterized by facial flushing, conjunctival congestion, blurred vision, headache, dizziness, nausea, vomiting, sweating, dry mouth, chest pain and other symptoms if alcohol is consumed after the drug is administered, and a few patients may die if not rescued in time. Drugs that cause disulfiram-like reactions include cefoperazone, cefoperazone sulbactam, ceftriaxone, cefazolin (Pioneer V), cefradine (Pioneer VI), cefadroxil (Pioneer IV), cefaclor, etc. Among them, cefoperazone has been reported to cause disulfiram-like reactions most frequently and most sensitively. In addition, metronidazole, tinidazole, ketoconazole, furazolidone, chloramphenicol, toluenesulfonylurea, glibenclamide, benzodiazepine, etc. can cause disulfiram-like reactions. As society continues to develop and people’s living standards continue to improve, we need to treat alcohol culture with a scientific attitude, establish the concept of “moderate drinking is good for health” and “excessive drinking is harmful to health”, and promote civilized drinking.