1, the treatment must be appropriate at present, Western medicine is mainly with hormones and immunosuppressive inhibitors, refractory renal syndrome treatment principle is: “the beginning of the dose to be sufficient, reduce the dose to slow, maintenance treatment to be long”. Cyclophosphamide is added when the hormone is reduced to the maintenance dose. If it is ineffective after regular treatment, or the effect is not obvious, it can be changed to cyclophosphamide or primaquine. A large number of clinical studies have shown that the combination of Chinese and Western medicine is currently a more effective treatment for renal syndrome. Combined with traditional Chinese medicine, it can strengthen the therapeutic effect of hormones and other western drugs and reduce their toxic side effects; especially for refractory renal syndrome, it can both reduce its recurrence and improve the cure rate. When using large doses of hormones, it is necessary to cooperate with herbal medicines for nourishing Yin and lowering fire; gradually add some herbal medicines for strengthening Yang and tonifying Qi during the hormone reduction phase; and reuse herbal medicines for strengthening the spleen and tonifying the kidney during the hormone maintenance phase. 2, prevention and control of colds may be more important than the treatment of medication often recurrent renal syndrome often relapses after a cold, timely prevention and control of colds is an important part of the prevention of renal syndrome relapse. For patients with renal syndrome, whether it is a bacterial or viral infection, which is usually referred to as a cold or flu, or other complications can aggravate the condition. Therefore, it is important to strengthen the awareness of self-protection to prevent complications. Among the many complications, colds are the most common and most easily ignored by patients, therefore, it is an extremely important aspect to pay attention to the prevention of colds. In case of sore throat, fever, runny nose, cough and other signs of cold, take Yin Qiao Xie Po tablets and Pioneer VI immediately, or seek medical attention. For patients who are weak and prone to colds, they can take the Chinese medicine Yu Ping Feng San for a long time to prevent colds. According to the theory of traditional Chinese medicine, nephrotic syndrome is caused by congenital deficiency or overworking, which leads to deficiency of internal organs and loss of qi, blood, yin and yang, and the essence of the disease is the deficiency of internal organs, especially kidney essence, and overworking can consume qi and injure fluid and aggravate the disease. We must pay attention to the appropriate amount of work and rest, not overwork (including physical and mental labor), so as not to aggravate the disease. Even after the disease is cured, attention should be paid to the combination of work and rest to avoid the relapse of the disease. Patients with severe edema and little urine should limit water intake appropriately. During high-dose prednisone treatment, or in patients with edema, a low-salt diet should be the mainstay, and the daily salt intake should not exceed 6 grams. Protein intake should be sufficient to maintain body needs and add the amount lost in urine, about 1 gram per kilogram of body weight per day, and can be increased appropriately for those with severe hypoproteinemia. Long-term excessive intake of protein is not only unhelpful to patients, but also increases the burden on the kidneys, which can lead to kidney function damage. At the same time, we should eat more fresh vegetables and fruits that are rich in vitamins. 4, do not use drugs or food that are damaging to the kidneys Any kidney disease, regardless of whether the kidney function has been damaged, can not use drugs or food that are damaging to the kidneys, so as not to aggravate the disease. Therefore, please keep in mind that you should not use or be cautious with the following drugs: aminoglycosides such as gentamicin, tetracycline, iodine-containing contrast agents, mercury, painkillers such as pau tai pine, finasteride and paracetamol in western medicine; mucuna pruriens, aristolochia, zebra, mercury and vermilion in Chinese medicine. Do not just believe in the so-called single or secret folk recipes, Chinese medicine is not completely non-toxic. Do not eat fish guts, dolphins and other toxic foods. Remind your doctor that you have kidney problems when you visit him/her so that he/she will not use the wrong medicine. In addition, for the treatment of frequent recurrent renal syndrome, I would also like to offer the following advice to patients: do not rush to the doctor, beware of quackery; try to go to the hospital with better equipment and higher technical level; listen to the doctor’s advice and insist on receiving treatment, do not give up halfway. As long as the treatment is appropriate, through the joint efforts between doctors and patients, many refractory renal syndrome can be cured.