Perioral dermatitis is usually due to allergic factors, or irritating factors resulting in a local inflammatory reaction, sometimes accompanied by local itching or burning sensation, the condition often fluctuates periodically, and the specific medication needs to be decided according to the patient’s specific situation. First, the use of fluoride toothpaste and corticosteroids containing fluoride should be stopped and all exogenous stimuli should be avoided. Second, commonly used topical creams include tacrolimus cream, butalbital hydroxy acid cream, and pimecrolimus cream, which can play a certain anti-inflammatory and antipruritic role when applied topically. If accompanied by significant pain or tightness, topical heparin sodium cream can be applied to relieve local dryness and pain. In Chinese medicine, a cold moist compress of honeysuckle decoction can be used locally on dermatitis, or a topical cooling ointment can be applied. Finally, in addition to treatment with topical creams, oral medications can be used. Clinical antihistamines are commonly used to control local itching and inflammation development, such as levocetirizine hydrochloride and loratadine, which can be combined with oral vitamin B2 and vitamin B6. Chinese medicine can be taken to strengthen the spleen and remove dampness soup, to remove dampness and strengthen the spleen, clear heat and detoxify the effect. If the inflammation is obvious you can add honeysuckle as appropriate, and if dry mouth occurs then you can add pollen, rehmannia, etc.