The disease is multifactorial. It is related to age and gender, with a genetic predisposition in most cases, and increased levels of androgens, leading to increased sebum production. In addition, seborrhea is often seen in neurological diseases such as Parkinson’s disease (Pakinson’s syndrome), especially in the progression of the disease, sebaceous gland secretion level can be higher than normal 2 times; in atherosclerosis, diabetes, adrenal tumors, some breast cancer patients and epileptic patients also have sebum secretion increased phenomenon.