I. What is systemic lupus erythematosus? Systemic lupus erythematosus is known in the rheumatological community as a beautiful woman’s disease because it occurs mostly in young women. In 1828, Biett, a French doctor, first reported such a patient who had irregular edematous erythema on the face like a wolf’s bite, with a depressed middle and raised edges and a smooth, sometimes scaly surface, and called this skin disease “lupus erythematosus”. With the accumulation of clinical experience, more and more doctors found that “lupus erythematosus” not only has skin damage, but also kidney, brain, heart, lung, blood, joint, muscle and other systemic lesions. SLE)” as the name of the disease. Lupus is not a description of its aggressive onset, but rather a figurative description. The most typical form of SLE has erythema across the bridge of the nose and both cheeks. It is commonly known as butterfly spots. Patients in Singapore call it “butterfly disease” to avoid the disgusting name “lupus erythematosus”, while patients in Taiwan call it “SLE” (SLE). Look at the white spots on the face of a wolf, are they not identical to the location of the butterfly-shaped red spots on a human face? The word lupus in Latin means an ulcer from a wolf’s bite, and it also means stubborn and difficult to treat. The treatment of lupus erythematosus is quite difficult. At present, lupus erythematosus is usually clinically classified into two types: those with lesions limited to the skin are called “discoid lupus erythematosus”, and those with lesions involving multiple internal organs and systems are called “systemic lupus erythematosus”. The former is mostly treated in dermatology, while the latter is mainly seen in rheumatology. Prolonged discoid lupus may develop into systemic lupus erythematosus. II. What are the conditions and symptoms of patients? Patients with SLE are widely distributed around the world, with large regional differences. It is estimated that there are about 1 million patients in China, and the trend is increasing year by year, mostly in women of childbearing age.SLE is a systemic disease, often with no specific manifestation at the beginning, mostly slowly, with unexplained fever, hair loss, joint pain, mouth ulcers, rash, muscle pain, weakness and other symptoms. There may be damage to only one organ, or it may affect several organs at the same time. III. What is the cause of the disease? Lupus erythematosus is one of the autoimmune diseases. The cause of SLE is related to infection, estrogen metabolism, environmental factors and genetic factors, and is a combination of multiple factors leading to abnormalities in the immune system. Under normal circumstances, T lymphocytes and B lymphocytes involved in the body’s immune response complement each other and maintain a functional balance. However, under the action of certain external environment or internal factors, such as virus infection, sun exposure, trauma, drugs, pregnancy, etc., the functions of the two types of cells are out of balance, and the functions of T lymphocytes are reduced while B lymphocytes are hyperfunctional, resulting in the production of various autoantibodies, such as anti-nuclear antibodies (including antibodies to nuclear proteins, DNA, etc.), antibodies to red blood cells, antibodies to white blood cells, antibodies to certain coagulation factors, etc. . These antibodies can react with the skin, blood vessels, heart, liver, kidneys, brain and other organs, and the antigen-antibody immune complexes are deposited in the connective tissue, resulting in organ damage. Fourth, can the disease be treated? If you know yourself and your enemy, you will never lose a battle. Systemic lupus erythematosus can be completely controlled clinically, and early standardized treatment determines success or failure. Early clear diagnosis can be made by examining autoantibodies, and the disease can be controlled in time when it has not yet affected internal organs, and better treatment results can be achieved. In the active stage, active treatment is needed, pay attention to the combination of work and rest, and keep a happy mood to prevent recurrence. At present, modern medicine mainly uses drugs, hormones, immunosuppressants, plasma exchange and other methods to treat SLE. the principles of treatment for this disease are: during the active stage of SLE, bed rest is the main reason for remission, and active treatment when there is infection; during the remission period, medication should be adjusted to reduce drug side effects and prevent recurrence of the disease. In addition to actively cooperate with treatment, daily care is also essential. General care: apply chloroquine cold cream on the face during outdoor activities, wear long-sleeved clothes and pants and wide-brimmed hats to reduce sunlight exposure to avoid aggravation of skin lesions. There should be curtains indoors. Dietary care: A high-calorie, high-vitamin, low-salt diet should be given, except for renal insufficiency, a high-protein diet can be given, and milk, especially colostrum, can be taken for a long time if possible, because colostrum contains a lot of antibodies, which can increase the immunity of the body. Moderate rehabilitation exercise: ensure sufficient sleep to reduce fatigue, and at the same time, participate in various activities, housework and rich recreational activities; moderate rehabilitation exercise and maintain a happy mood is conducive to the remission and control of the disease. Most patients can be in long-term remission and work and live like normal people.