Muscle atrophy after lower extremity DVT is caused by the normal blood supply to the muscles being affected. It is recommended to treat the thrombosis actively and improve the atrophied muscles through rehabilitation exercises. The formation of DVT in the lower limbs will block the normal blood circulation, and the normal blood supply to the local muscles will be abnormal after the blood circulation is poor, and the long-term ischemia and lack of oxygen will lead to muscle atrophy. It is necessary to actively treat DVT in the lower limbs, and the thrombus can be removed through surgical intervention; it is also necessary to avoid prolonged bed rest, and some patients need to take oral anticoagulant drugs such as warfarin to prevent recurrence of the thrombus, and the drugs should be used in accordance with the doctor’s instructions. In addition to the treatment of DVT, it is also recommended that the patients actively carry out rehabilitation exercises to improve muscle atrophy and restore the normal function of muscles as far as possible.