Both physiological and pathological factors can lead to fatigue, and appropriate drugs should be chosen according to the different causes. Medicines to restore energy for fatigue caused by physiological reasons include Liou Wei Di Huang Pill and Ginseng Qui Shen Pill, etc. For fatigue caused by pathological factors, you can choose sertraline, paroxetine and other medicines. In daily life, many people will have a sense of fatigue, fatigue may be physiological factors, but also may be caused by pathological factors. 1. Physiological factors: staying up late at night, lack of sleep, the brain and body do not get enough rest, the next day there will be fatigue. Malnutrition and insufficient qi and blood will also make people feel fatigued. At this time, it is recommended to adjust living habits, reduce the frequency of staying up late, pay attention to supplemental nutrition, eat more meat, eggs, milk, to enhance physical fitness, you can also follow the doctor’s instructions to take Chinese medicines, such as six flavors of the earth pill, ginseng spleen pills to restore physical strength. 2. Pathological factors: such as depression, patients often feel lethargy, can not do anything to raise the spirit, can not interest, feel very fatigue, if there is such a performance, it is recommended to go to the hospital as early as possible, follow the doctor’s instructions to take antidepressants, such as sertraline, paroxetine, and so on. It is recommended that patients follow the doctor’s instructions, reasonable use of medication.