The first thing to consider is whether the stomach acidity and heartburn in the middle of the night is related to the food consumed, such as consuming too many desserts, sweets and spicy stimulating food can cause acid reflux and heartburn in the stomach. If the acidity and heartburn are prolonged, it is advisable to have a gastroscopy to exclude gastritis, gastric ulcer, bile reflux gastritis and other diseases, and then to add drugs for oral treatment according to the symptoms. Commonly used drugs include proton pump inhibitors such as omeprazole enteric capsules, lansoprazole, rabeprazole and esomeprazole, etc., and gastric mucosal protectors such as bismuth aluminate granules, bismuth pectin, aluminum phosphate gel, aluminum thioglycollate, etc. If combined with abdominal distension, anorexia and other discomfort, you can add domperidone, mosapride to promote gastrointestinal motility, stomachic elimination tablets, pancreatic enzyme enteric soluble tablets orally to help chemotherapy, usually eat more millet porridge, yam, dates and other foods to protect the spleen and stomach.