Calf soreness and swelling when sleeping is mainly seen in spasm and edema caused by excessive force pulling on the muscles and fascia of the calf area, as well as in patients with varicose veins and venous valve closure insufficiency in the lower limbs, which cause calf stasis when standing and having calf soreness and swelling when sleeping in bed. After this happens, one is to elevate the affected limb when sleeping to facilitate the reflux of lower limb veins and promote the decreasing of edema and stasis of blood. The second is to apply heat to the calf area to promote blood circulation in the calf area and massage the calf area after applying heat to relieve the symptoms of calf soreness and swelling. If necessary, you can take oral non-steroidal anti-inflammatory drugs, such as nimesulide, diclofenac sodium, ibuprofen and other drugs to reduce the symptoms.