The symptoms of sore calves while sleeping are mostly caused by impaired blood circulation in the calves. It is necessary to perform calf manipulation massage before going to bed, using local rolling method, holding and kneading method, point pressure method, etc. Each manipulation massage is 3-5 minutes, and the total massage time does not exceed 20 minutes. After the massage, the legs will be elevated, the overall height is higher than the heart, so that the lower extremity veins blood back to the heart, but also can make the dilated veins gradually contract, to reduce the symptoms of calf soreness and swelling. Oral horse chestnut seed extract tablets can promote blood return, so that the symptoms of sore and swollen calves can be quickly relieved, and if the pain is serious, oral fenpropathrin can be used to relieve pain. Patients who have enough time can go to a regular hospital during the day for acupuncture treatment, or use local magnetic therapy, electrotherapy and other physical therapy methods, which can effectively relieve the soreness.