Entrapment pain is a specific form of pain. Its pathogenesis is characterized by the occurrence of pain at a site other than the primary site of the lesion, which is mainly related to the conduction of pain and has its own specific anatomical basis. It is not uncommon for referred pain to occur in the pathogenesis of a disease and to be characterized by the occurrence of pain at one site and pain at another site, or even in some cases where pain does not occur at the primary site but first occurs at another site, a phenomenon that can be observed in many diseases. Acute appendicitis is a disease of the appendix, and in the early stages of the disease, it may produce very pronounced involvement pain. The appendix is located in the right lower abdomen, and in the early stages, it may produce pain in the upper abdomen or around the belly button; tooth pain is also a common example of involvement pain. The occurrence of involvement pain has its own specific conduction and anatomical basis in conduction. Pain production requires nerve endings to pass through conduction into the dorsal horn of the spinal cord, and then through the intermediate transducer of the spinal cord to the nociceptive center in the brain, where the person feels the pain. In the middle of this, the spinal cord is the low-level pain perception center and the brain is the high-level perception center. The spinal cord does not feel pain with a specific organ, but with a certain plane of the body to collect pain information. Therefore, when pain occurs in the same horizontal plane or in planes not far apart, the spinal cord does not precisely analyze which specific organ of these planes is the source of pain information, and when it reaches the higher pain center of the brain, the brain will also misjudge the organ of pain occurrence, which is the conduction and anatomical basis of the occurrence of implicated pain. This is the conduction and anatomical basis for the occurrence of referred pain. The cause is the “misrepresentation” of the dorsal horn of the spinal cord. Entrapment pain is an uncommon condition. Therefore, after the onset of pain, do not mistake any part of the spinal cord for a problem, but be patient and cooperate with your doctor in the diagnosis of the disease.