H. pylori infection is a curative factor for many diseases of the digestive system. If the test is positive for H. pylori, anti-H. pylori treatment should be performed; otherwise, it can cause gastritis, gastroduodenal ulcer, and even gastric cancer, duodenal cancer and other diseases. There is no single drug on the market that can eradicate H. pylori alone, but usually a combination of drugs is used to treat it. Such as triple therapy, quadruple therapy, etc. Triple therapy includes one kind of proton pump inhibitor plus two kinds of antibiotics, proton pump inhibitors are usually chosen clinically as omeprazole enteric capsules, rabeprazole sodium enteric capsules, pantoprazole sodium enteric capsules, antibiotics can be chosen from penicillins, quinolones, aminoglycosides, macrolides, furans, etc. Clinically, the triple therapy of amoxicillin + clarithromycin + rabeprazole sodium enteric capsules is taken for 10-14 days and then stopped for 1 month. After 14 days, the eradication rate is relatively high when the drug is stopped for 1 month and rechecked. If it is still positive, a bismuth agent, such as colloidal bismuth pectin, bismuth potassium citrate, bismuth aluminate, etc., should be added to the above triple therapy for the purpose of auxiliary sterilization. After performing anti-H. pylori treatment, it should be reviewed, and if it is still positive, it should be replaced with a sensitive antibiotic to sterilize the treatment again. Furthermore, care should be taken to prevent reinfection after anti-H. pylori treatment.