Warfarin is an anticoagulant that must be taken after valve replacement. It should be used in strict accordance with the physician’s instructions, and the physician should be consulted frequently until it is clarified. 1.When blood clots, vomiting of blood, fresh blood or tarry stools, bleeding gums, blood in sputum, purpura, chest pain, pelvic pain, headache, dizziness, prolonged bleeding after minor trauma or any symptoms of hepatitis (darkening of urine, itching of skin, jaundice, light-colored stools, clay color) occur, the drug should be discontinued immediately to contact your physician. 2.Take the medication at the same time every day and should not change the dose or brand of the medication without the doctor’s permission. If you miss a dose of the medication you need to make it up as soon as possible, but you should not increase the dose to make up for it. 3. Do not take other medications, including aspirin and cold medications, without your doctor’s permission. These drugs can interfere with the effects of Warfarin and cause health hazards. 4.Influenza vaccine makes the effect of anticoagulation increase, check for bleeding within one month of vaccination. 5.Fever, climate fever, malnutrition and diarrhea can prolong the clotting time causing bleeding. 6.Keep a balanced, relatively regular diet and good eating habits, and keep in mind to eat less high-fat diet and foods rich in vitamin K such as: cabbage, cauliflower, asparagus, lettuce, green radish, fish, liver, etc. 7, avoid alcohol abuse. Drinking alcohol can accelerate the metabolism of Warfarin and shorten the bleeding time. Avoid trauma and bleeding as much as possible. 8.Use a soft toothbrush, shave with an electric razor, wear gloves when cultivating flowers and plants, and check with your doctor before participating in sports to see if your physical condition is unfit for exercise. 9, quit smoking or smoke as little as possible, smoking can speed up the metabolism of the drug need to adjust the dosage. 10, Warfarin can cause miscarriage, stillbirth, fetal malformation, if the patient is pregnant or preparing to become pregnant please tell the doctor. 11.Patients should tell their doctor that they are taking Warfarin when they see other diseases, and they must indicate that they are receiving Warfarin treatment.