Some symptoms will remain after the acute phase of MS, and these symptoms may take longer to recover. For those patients with more severe symptoms, the following methods of treatment can be applied. In addition, these symptomatic treatments are also applicable to the sequelae of optic neuromyelitis optica: 1. painful spasm: drugs such as carbamazepine (oxcarbazepine is currently more commonly used), gabapentin and baclofen can be applied. 2, chronic pain, sensory abnormalities, etc.: available amitriptyline, pregabalin, selective 5-hydroxytryptamine and norepinephrine reuptake inhibitors (SNRI) and norepinephrinergic and specific 5-hydroxytryptaminergic antidepressants (NaSSA) class of drugs. 3, depression and anxiety: selective 5-hydroxytryptamine reuptake inhibitors, SNRI, NaSSA drugs and psychological counseling treatment can be applied. 4, fatigue, fatigue (MS patients more obvious symptoms): available modafinil, amantadine. 5.Tremor: Benzhexol hydrochloride, Aurolol hydrochloride and other drugs can be applied. 6, bladder rectal dysfunction: with drug therapy or intermittent sterile catheterization and other treatments. 7, sexual dysfunction: can be applied to improve sexual function drugs, etc. 8, cognitive impairment: can apply cholinesterase inhibitors, etc. 9, recalcitrant erratic: baclofen, 654-2, gastric reversion, etc.