When papular urticaria blisters, patients usually do not puncture themselves to avoid infection, and need to go to a regular hospital for treatment. Papular urticaria is mainly due to the patient’s contact with allergens caused by the situation, the emergence of inflammatory substances, causing vasodilatation, its permeability increases, resulting in the symptoms of blistering. If the patient’s blisters are relatively large, they can be treated with puncture drainage, which requires going to the hospital, and avoiding picking them on their own to avoid infection. Patients can also use compound flumethasone ointment, flufenamic acid butyl ester ointment and other drugs to treat. Patients with papular urticaria should follow the doctor’s instructions for medication in daily life, avoid scratching to avoid infection, and seek medical attention when symptoms worsen.