Herpes simplex virus (HSV) infection is common and it is wrong to let it spread without awareness of the disease, but it is also wrong to spend too much energy and money to seek a cure (some patients spend hundreds of thousands of dollars to seek a cure, which is too costly and causes psychological stress). Genital herpes is an HSV-2 infection, mainly seen in sexually active people, characterized by easy latent sensory neurons and skin mucous membranes, intermittent detoxification and the appearance of clinical symptoms. Most of the infections are unintentional and the clinical manifestations of the infection are determined by the immune status of the host, so it is difficult to estimate the incidence of the disease if more people are infected than have clinical symptoms. Limiting the number of sexual partners and using condoms correctly can reduce the chance of infection. Prompt treatment and avoidance of sexual contact during the acute phase can reduce transmission. About 70% of newborns are infected through the birth canal, and a few are infected by intimate contact with adults (e.g., kissing of patients with oral and labial herpes). According to the survey, the incidence of neonatal herpes is 30%-50% in pregnant women with primary (i.e., first infection) genital herpes in recent deliveries, but the incidence of neonatal herpes is only 3% in pregnant women with recurrent herpes in the past. This means that pregnant women who have developed HSV-2 antibodies in their serum are at little risk of neonatal infection and should not be blindly afraid. Avoiding predisposing factors such as colds, stress, too-tight underwear friction and factors that lead to a decrease in immunity can reduce recurrence. If the disease is treated with a normal mindset and in a regular hospital dermatology department, many patients will have less and less frequent attacks in about 5 years. I hope that patients suffering from this disease will not be cheated by some profit-oriented medical institutions and cause a heavy psychological burden.