It is common for some patients to have a dry cough. The use of cough medicine does not seem to work, some are the cause of the disease, and some may be caused by drugs. Antihypertensive drugs: Two types of commonly used antihypertensive drugs may cause the adverse reaction of dry cough. One type of drug is the ACEI class, commonly used drugs such as captopril, fosinopril, benazepril and enalapril, which have a high incidence of causing cough after taking. Another category is the angiotensin II receptor antagonist (ARB) class of antihypertensive drugs, commonly used drugs include valsartan, coxsartan, irbesartan, and telmisartan. These antihypertensive drugs can provide very similar efficacy to ACEI, but the symptoms of dry cough are not as pronounced. The dry cough caused by antihypertensive drugs is like choking accidentally on a drink of water, manifested as a persistent irritating dry cough, mostly accompanied by pharyngeal itching and foreign body sensation in the pharynx; moreover, this dry cough will worsen at night or when lying down, and other uncomfortable symptoms such as nausea and vomiting may occur in severe cases, with a higher incidence in female patients and elderly patients. Antiarrhythmics: Amiodarone can cause diffuse interstitial or alveolar lung disease and occlusive fine bronchitis with organizing pneumonia (BOOP), which are sometimes fatal. If dyspnea or dry cough develops, either alone or in combination with a worsening systemic state (fatigue, weight loss, fever), radiological controls need to be performed and, if necessary, then treatment needs to be suspended. These forms of lung disease can actually progress to pulmonary fibrosis. Adrenocorticosteroids may be used to provide relief. Early discontinuation of amiodarone can lead to recovery of this disorder and clinical signs usually disappear within 3 or 4 weeks. Radiographic and functional improvement is usually slower (several months). Antineoplastic agents: bleomycin can cause dry cough, dyspnea, and fever. It often occurs in older patients (over 70 years of age). Cyclophosphamide: can cause cyclophosphamide pneumonia. Methotrexate: manifests as cough, dyspnea, low-grade fever, and wet rales. Discontinuation and addition of corticosteroids are mostly effective. Exemestane, anastrozole and letrozole for breast cancer can also cause cough. Anti-allergic drugs: Sodium cromoglycate can cause transient hypersensitivity. It manifests as nasal congestion, cough, croup, bronchospasm, aggravation of existing asthma, pulmonary edema, pulmonary eosinophilic exudation, allergic reaction, and in severe cases can be fatal. Anti-Parkinsonian drugs: Bromocriptine mainly causes cough, dyspnea, pleural thickening, pleural effusion. Anti-epileptic drugs: Carbamazepine can cause acute pulmonary hypersensitivity reactions. Anticoagulants: such as heparin and warfarin can cause cough due to bleeding in the chest or lung parenchyma. Diuretics: hydrochlorothiazide can cause acute attacks of interstitial pneumonia and non-cardiogenic pulmonary edema. It manifests as asthma, cough, croup and hypothermia a few hours after drug administration. Manage with aminophylline and corticosteroids and mechanical ventilation if necessary. Avoid reuse. Anti-ulcerative colitis agents: salazosulfapyridine can cause cough, dyspnea, pulmonary infiltrates, elevated peripheral blood eosinophils, fever, occlusive fine bronchitis, and fibrosing alveolitis. Corticosteroids are available to improve symptoms. Antituberculosis drugs: para-aminosalicylic acid can cause hypersensitivity-like reactions, manifested as fever, rash, headache, dry cough, croup, angioneurotic edema, elevated eosinophils, alveolar infiltration, lymph node enlargement, pleural effusion, and hepatomegaly. Corticosteroids may be used to improve symptoms. Antimicrobial agents: furantoin can cause sexual pneumonia (acute, chronic, interstitial). Present with dyspnea, dry cough, rash, malaise, arthralgia, chest pain, fever, wet rales in the lungs, pleural effusion, cyanosis, hypertension, and croup. Treatment is to discontinue the drug and add corticosteroids and antihistamines to relieve symptoms. Gold agents: can cause diffuse interstitial pneumonia and fibrosis. It manifests as subacute progressive dyspnea and dry cough lasting several weeks, with fever and croup. Treatment is discontinuation of the drug and addition of corticosteroids.