The test proved that the outpatient clinic patients with venereal diseases, according to the principle of voluntary psychological testing, and the experimental group of mental health guidance to analyze the patients with venereal diseases in the conventional treatment at the same time as psychological health guidance, is able to shorten the recovery time of the disease. In particular, the recurrence rate of patients with acromegaly is significantly lower than that of patients without psychological guidance, and the cure time is shortened. CONCLUSION: The efficacy of psychological health guidance in the conventional treatment of patients with condyloma acuminatum at the same time is obvious. In the statistics of outpatient treatment, the recurrence rate of patients with condyloma acuminatum aged 30 to 40 years was significantly higher than that of patients of other ages. The recurrence rate of patients with intermediate literacy is again significantly higher than that of patients with low literacy. The incidence rate of higher culture is significantly reduced. Reason analysis: 1, this age of the patient psychological pressure, the body immunity also because of the age of the problem has declined. 2, this age of patients generally have old and young, in the community has a certain status, worried about letting people know that they have sexually transmitted diseases and can not face the near people, acquaintances. Thus, the excessive fear of the psychological. 3, some of them let their spouses know that they have sexually transmitted diseases, thus causing family disputes, family pressure is not conducive to the complete eradication of the disease. 4, acromegaly treatment requires the patient within three months can not cohabit, this age patients often due to a variety of reasons can not do, there may be a recurrence of infection. 5, especially the female patients not only endure the physical pain, more importantly, psychological has more heavy mental torture, patients once diagnosed with sexually transmitted diseases that appear self-blame, anxiety, depression and even mania and other general disease patients often have mental health problems. The number of patients with STDs is on the rise, the incidence of the region and the scope of the gradual expansion of the harm is becoming more and more serious. The spread of STDs has had a serious impact on families and society, especially threatening the physical and mental health of women. With the change of medical model, in the diagnosis and treatment of disease at the same time, should pay attention to the psychological status of patients, the same is true for patients with sexually transmitted diseases. Understanding the patient’s psychological state, in order to take appropriate mental health guidance, eliminate or reduce the patient’s adverse psychological problems, which plays a positive role in the treatment of the disease and the improvement of the patient’s quality of life. Mental health guidance: 1, listen carefully to the patient’s confession, so that it relieves the pressure: confession is one of the most common and effective ways to relieve pressure, so that the patient will increase the sense of trust in you; at the same time, mental health guidance, exclude the patient’s nervousness, so that it relieves the unnecessary psychological pressure. 2.Patiently and in detail, introduce the characteristics of the disease and precautions to the patient. 3, the necessary postoperative precautions:: pay attention to the vulva clean; do not drink, do not eat spicy and other stimulating food; pay attention to rest, appropriate to strengthen the physical exercise, pay attention to sexual hygiene, the strict implementation of monogamy is the key to preventing sexually transmitted diseases.