Cancer bone metastasis is one of the main causes of cancer pain, and the complications caused by it, such as pathological fracture, spinal cord compression and hypercalcemia, can accelerate the development of cancer patients’ disease and seriously affect their survival quality. With the improvement of living standard and the update of medical concept, we should not take a negative attitude towards bone metastasis, but should realize that metastasis of cancer does not mean the end of life, and proper treatment can have definite effects in reducing pain, improving the quality of survival and prolonging life. Bone metastatic cancer pain is a common cause of bone pain in advanced cancer patients, and it is usually very severe, intermittent or persistent, and worsens day by day. Such pain is especially severe at night, which makes patients fear and worry a lot before going to sleep. The localized pain of bone metastases ranges from dull pain to deep and unbearable severe pain. It often worsens during activities and weight bearing. When pathological rib fracture occurs, the pain is most severe when changing from sitting position to supine position or opposite movement or trunk side lying. Bone metastases cause bone pain by a variety of mechanisms, including activation of endosteal or periosteal injurious stimulus receptors caused by mechanical deformation or release of chemical mediators, as well as tumor extension into adjacent soft tissues or surrounding nerves, compression of nerves, muscle spasm and associated myofascial pain. Treatment of Bone Metastatic Cancer Pain Treatment of bone metastatic cancer pain is still a difficult problem faced by clinicians and is classified as refractory cancer pain. The principle of treatment should be a comprehensive and integrated treatment that varies according to the condition, including drug therapy, nerve block, nerve destruction, radiotherapy, nuclear therapy, chemotherapy and surgery. At the same time of treatment, we should pay attention to the psychological treatment of patients and actively improve their quality of life. The use of strong long-acting opioids and non-steroidal anti-inflammatory drugs, if used properly, the pain of a significant proportion of patients can be well controlled. The WHO three-step cancer pain treatment program has been widely accepted internationally as the main method of cancer pain treatment. In China, WHO three-step cancer pain treatment is implemented. Updating the concept and strengthening cancer pain treatment education are two key issues here. The latter includes professional education and public education to make professionals fully aware of the importance of controlling cancer pain and, at the same time, to convince patients that cancer pain can be completely controlled. Principles of applying analgesic drugs: The WHO three-step cancer pain drug treatment method is based on the concept of “ladder” of drug delivery method, and five basic principles should be observed in drug delivery: oral, on time, according to the ladder, individual differences in drug use and attention to specific details. 1, the best use of oral administration; 2, according to the step of drug delivery; 3, on time, to avoid the need to give drugs; 4, individualized drug delivery, so the choice of opioids, should try to achieve dose titration; 5, pay attention to the specific details, to patients can get the best efficacy and the occurrence of adverse reactions is minimal. (1) Non-steroidal anti-inflammatory drugs: For simple bone metastatic cancer pain, large doses of non-steroidal anti-inflammatory drugs can be given to inhibit the synthesis of prostaglandins in bone tissues, which can often obtain curative effects. The traditional NSAIDs include aspirin, ibuprofen, indomethacin, acetaminophen, etc. Their disadvantages are strong side effects. The better NSAIDs: celecoxib and rofecoxib. (2) Opioids: opioids have certain effects on bone metastatic cancer pain, and can achieve complete analgesia for some milder patients. However, since bone pain is a semi-responsive pain to opioid drugs, the application of opioid drugs alone often cannot achieve satisfactory therapeutic effect, which should be paid special attention in the treatment of bone metastatic cancer pain. Tramadol, morphine, fentanyl transdermal patch, morphine controlled-release tablets, OxyContin, etc. (3) Parmiphosphate disodium: Disodium phosphate is the 2nd generation bisphosphonate bone metabolism improver after bone phosphorus, which has a strong effect of inhibiting bone resorption. It has been used in the treatment or prevention of osteolytic bone metastases and hypercalcemia of malignant tumors. It has a significant analgesic effect on pain caused by osteolytic bone metastases of malignant tumors. As a new generation of bisphosphonate osteolysis inhibitor, Parmiphosphate disodium can stably bind to the surface of bone trabeculae and hinder the osteolytic effect of osteoclasts; inhibit the activity of osteoclasts; inhibit the transformation of osteoclastic precursors to osteoclasts, thus reducing bone destruction and resorption and alleviating the pain caused by bone metastases, without any significant adverse effect on bone growth and mineralization. Nerve block For patients with limited scope of cancer pain from bone metastases, local anesthetics can be applied to block the nerve roots and nerve trunks related to cancer pain, so as to relieve cancer pain. The disadvantage is that the analgesic time is short and the effect only lasts for a few hours. It can be used as an emergency analgesic method in acute cancer pain attacks, and since opioid receptors have also been found in peripheral nerve tissues, narcotic analgesics can be added into the solution to improve the therapeutic effect and prolong the time. Intrathecal injection is considered to be one of the most effective methods for treating cancer pain, with small dosage and few side effects, and the ratio of oral dosage is one in three hundred. Fourth, selective nerve destruction, i.e. irreversible damage to the innervated nerves in the pain area, but the nerve damage is irreversible.