Biliopancreatic malignant tumors include bile duct cancer, gallbladder cancer and pancreatic cancer. Since most patients are already in the middle and late stages when they are found, the prognosis is extremely poor, and the 5-year survival rate is only 5%, which is called the “king of cancer”. However, research shows that the surgical resection rate of early biliopancreatic malignant tumors can be more than 60%, and the 5-year survival rate is more than 50%. What makes the “king of cancers” so difficult to be overcome for a long time? What are the common misunderstandings of patients in the process of medical treatment? The early symptoms of bile duct cancer, gallbladder cancer and pancreatic cancer are not obvious, or even completely asymptomatic, which makes the disease easy to be missed. Some patients do not pay attention to the hidden pain and abdominal distension, thinking that it is a minor disease such as gastritis or stomach disease, and do not seek medical treatment in time. The best time for treatment is lost. 2, physical examination are normal At present, health checkups have been accepted by more and more people, many patients have normal physical examinations over the years, but suddenly found to be biliopancreatic malignant tumors in advanced stages and why? Because the common tumor indicator of biliopancreatic tumor is CA199 elevation, which is not included in many medical checkup centers, and the ultrasound of abdomen is only applicable to check the gallbladder, while the interference of bile duct and pancreas due to gas affects the detection of bile duct cancer and pancreatic cancer. The physical examination report is normal, but many patients have the psychology of reluctance to seek medical treatment and ignore the existence of biliopancreatic malignant tumors. When abdominal pain and other discomforts occur, many patients first think of gastritis, stomach disease and cholecystitis, so they take gastric medicine by themselves, go to gastroenterology for the first time to treat gastritis, go to general surgery to treat cholecystitis for patients with gallbladder stones, and also go to Chinese medicine to adjust the symptoms. These common misconceptions lead to the discovery of biliopancreatic malignant tumor only after the patient has gone through a series of treatments and the symptoms have not improved. Therefore, when abdominal pain occurs, one should be alert to the possibility of biliopancreatic malignant tumor. Biliary and pancreatic malignant tumors require standardized treatment with the cooperation of multiple disciplines, rather than indiscriminate treatment. Research shows that the resection rate of biliopancreatic malignant tumor is less than 30%, but under the treatment of specialized team, the resection rate can reach 70%, and even many middle and late stage biliopancreatic tumors can be radically resected. Unfortunately, it is difficult for many patients to receive standardized treatment from specialized teams. In addition, metal stents need to be placed with extra caution. Many patients who have the chance of surgery have lost the chance of surgery due to the placement of metal stents. Tip 1: If you have the following conditions: unexplained weight loss or diabetes mellitus, low back pain, painless jaundice, you need to seek medical attention promptly and be alert to the possibility of biliopancreatic malignancy; Tip 2: Regular follow-up of benign biliopancreatic diseases, including: gallbladder polyps, gallbladder stones, intrahepatic bile duct stones, common bile duct cysts, adenomyosis of the gallbladder, chronic pancreatitis. With the goal of “increasing the rate of radical resection, prolonging patients’ lives, and improving the quality of life”, we vigorously carry out radical surgery for various biliary and pancreatic malignancies, including radical surgery for type IV hilar cholangiocarcinoma, radical surgery for gallbladder cancer combined with hemihepatectomy, radical surgery for enlarged pancreaticoduodenum, and pancreaticoduodenectomy with preservation of the pylorus. We have achieved good clinical efficacy by adopting integrated treatment of radiotherapy and chemotherapy for patients with advanced pancreatic cancer. We have saved the lives of many patients with biliopancreatic malignancies through accurate preoperative imaging and systemic assessment, precise surgical planning, and delicate surgical operations.