Cholesteatoma otitis media refers to cholesteatoma of the middle ear, and the main symptoms include ear pus, hearing loss, vertigo, facial nerve paralysis and so on. 1. Ear pus: purulent secretion with strange odor, related to Pseudomonas aeruginosa infection, the amount of purulent secretion is related to the degree of infection. The amount of purulent secretion is related to the degree of infection. There may be bloody secretion when the inflammation is heavy and there is granulation tissue growth. 2. Hearing loss: patients may have different degrees of hearing loss, and the degree of hearing loss is related to whether the auditory conduction pathway is normal. 3. Vertigo: the destruction of the labyrinthine bone wall can form a labyrinthine fistula, which can lead to vertigo, and bacterial toxins can cause inflammation of the labyrinth can also produce vertigo. 4. Facial nerve paralysis: Facial nerve paralysis is related to cholesteatoma compression and erosion of facial nerve, and also related to infection involving facial nerve. Patients with middle ear cholesteatoma need to go to the hospital in time, follow the doctor’s instructions for targeted treatment, and avoid self-medication.