The treatment of bedwetting, or enuresis, should first clarify whether it is primary or secondary enuresis and choose the appropriate treatment depending on the cause. Enuresis usually refers to the involuntary urination of a child while sleeping. Primary enuresis refers to enuresis without obvious neurological lesions or urinary system lesions, and is mainly caused by several etiologies, including delayed cortical development and deeper sleep. Secondary enuresis is mainly due to congenital spina bifida and neurogenic bladder. Most children with primary enuresis will resolve themselves by adulthood, while a few patients may continue to have symptoms into adulthood. Treatment is equally effective with behavioral therapy and medication. A small number of patients may continue to have symptoms into adulthood, and most enuresis is associated with a genetic predisposition. Behavioral therapy includes regular micturition training and holding training to help reduce the incidence of nocturnal enuresis in children. Medications include promethazine, ephedrine, and desmopressin. Treatment of the primary cause such as spina bifida may result in remission or disappearance of enuresis. Therefore, treatment of bedwetting still requires a combination of behavioral therapy and medication, and treatment of the primary cause is equally important. In summary, the etiology of enuresis mainly includes developmental delay and neurological lesions. Primary enuresis can often be cured spontaneously, but for those caused by secondary diseases, the primary disease should still be actively treated, while behavioral treatment should be taken to improve bedwetting symptoms.