Among the three major diseases that threaten human life span, infectious diseases are the first in terms of history; in terms of absolute mortality, cardiovascular diseases are the most important; but in terms of complex and expensive treatments, tumors are the only ones. Most tumors are difficult to treat. About 100 years ago, it was recognized that surgery, radiotherapy and chemotherapy had definite efficacy on them. Now that 100 years have almost passed, human understanding of tumors has undergone a sea change: surgery is more sophisticated, radiotherapy equipment is more precise, and drugs are more effective, and the therapeutic effect of many tumors has been greatly improved and even miraculous with medical intervention. Although the main means of effective cancer control has undergone subtle changes in its status and importance, its limitations have not changed greatly: surgery wants to cure early tumors, but most early tumors are difficult to detect; even after radical lung cancer treatment at stage I, its 5-year recurrence rate is more than half. Radiotherapy tries to eliminate the tumor by local irradiation, but often the normal tissues next to the tumor are not tolerated before the tumor is killed; or although the tumor is eliminated locally, distant metastasis occurs; in a few cases, the tumor is cured by radiotherapy, but most patients have to suffer the toxic side effects brought by radiotherapy more or less. Cytotoxic drugs try to kill tumor cells by wheel tactics, but most of the treatments are either ineffective or eventually resistant and all drugs are no longer effective, and only a few patients finally escape from cancer treatment. The latest data from the United States shows that after standardized treatment, the survival time of tumor patients is about 60% over 5 years, however, the current situation in China is that about half of the cancer patients die within five years after the onset of the disease. Even if the survival time exceeds 5 years, there are still a considerable number of people surviving with tumors, and many patients have quite heavy symptom load and low quality of life. For the current level of technological development, it is unrealistic to significantly increase the cure rate of tumors. The variety of treatment methods tells us how helpless human beings are in most cases in front of cancer. Looking back at the tremendous advances in tumor treatment technology over the past 100 years, it seems that the improvement in cancer cure rates has been insignificant. Yet we seem to have artificially exaggerated the effectiveness of treatment, with overtreatment at our fingertips: chemotherapeutic drugs with an efficiency of only about 30% are heavily used in the inoperable phase of lung cancer, and about 70% of patients are treated by trial and error to obtain an extremely short life extension for only a few patients. Many procedures are performed without rigorous evaluation, only to find that the tumor cannot be removed intraoperatively, or the procedure is done and the patient dies in the perioperative period. We pay attention to investigate the prevalence of disease occurrence, but are too indifferent to the irrational or wrong medical treatment that occurs around us. It is time for us to seriously reflect and declare war on blind medical procedures. In addition to pilot studies, we should opt for treatments that have clear efficacy. Happily, in the age of information and evidence-based practice, this is not difficult to do. Rehabilitation medicine, palliative medicine, evidence-based medicine, translational medicine, integrative medicine ……. The proliferation of ideas reflects a courageous reflection on the value and function of medicine. It is time for us to reconceptualize the mission and meaning of medicine: how to choose the most valuable diagnostic assessment plan for the first diagnosis of tumor? How to maximize the efficacy but minimize the risk of treatment plan after the first diagnosis? How to choose a comprehensive rehabilitation program after effective treatment? Are large scale indiscriminate herbal treatments really effective, or are they just psychological comfort? With increasingly clear molecular markers and accumulating evidence-based data, can we make treatment more individualized? What do patients need most in their dying days, in the final moments when the efficacy of all treatments is uncertain: a futile and painful battle? Or a relieved and quiet departure?