Is this disease easy to diagnose and can it be easily confused with other diseases? Primary amyloidosis is a rare disease, and many doctors have rarely seen or heard of this disease, so the attention is very low. In addition, this disease can damage many important organs and has no characteristic manifestations, so many patients are initially treated as kidney disease, cardiovascular disease, or gastrointestinal disease. In fact, it is not difficult to diagnose primary amyloidosis as long as people are aware of it and pay attention to it. For patients with multiple organ damage, as long as the doctor can think of the possibility of primary amyloidosis and perform a puncture biopsy of the damaged organ, the majority of patients can be diagnosed clearly. Currently, kidney biopsies are more commonly done, but bone marrow biopsies, subcutaneous fat biopsies of the abdominal wall, gastrointestinal mucosal biopsies, and even myocardial biopsies and liver biopsies can also be done. Can a blood test detect the disease? Can the diagnosis be confirmed? A blood test can only detect malignant plasma cell disease, not diagnose amyloidosis. A tissue biopsy is required to confirm the diagnosis of true primary amyloidosis. If it is a cardiac lesion, how is it biopsied? Do I need to open my chest? No, it is not necessary to open the chest. If it is a heart lesion, a myocardial biopsy should be done, which is done through an intravenous catheter and is commonly performed abroad. In fact, myocardial biopsy is a relatively safe and invasive test, but it is not performed much in China. Since most patients will have kidney problems at the same time, and the kidney biopsy technology is mature, the risk is relatively small, and the patient can easily accept it, so most patients are diagnosed by kidney biopsy. Do I need genetic testing for this disease and what is the use of genetic testing for this disease? Although primary amyloidosis is a malignant plasma cell disease and so far no significant correlation has been found between a particular gene and the diagnosis of this primary amyloidosis, clinical studies have shown that the presence of certain diseases may have a relationship with the treatment of primary amyloidosis. For example, if certain genes are abnormal, then the patient’s treatment outcome may be affected. What is the cost of a complete set of tests to confirm a diagnosis of primary amyloidosis? For a single biopsy, the cost is about a few thousand dollars; however, for a complete set of tests, including a bone marrow aspiration biopsy, genetic tests, and chromosomal tests, the cost is higher, about seven to eight thousand dollars. Overall, the total cost for a full set of tests for a patient is more than$10,000.