What are the risks associated with primary amyloidosis? Amyloid material, consisting of monoclonal light chains, can travel throughout the body with the blood and can be deposited in various tissues and organs of the body and cause damage. The most popular tissues and organs for amyloid deposition include kidney, heart, liver, lung, intestine, blood vessels and nerves. When a certain amount of amyloid is deposited in tissues and organs, the function of tissues and organs will become abnormal, and patients will exhibit kidney problems such as proteinuria and renal insufficiency; cardiovascular problems such as arrhythmia, cardiac insufficiency, cardiomegaly and low blood pressure; and liver function, lung function and nerve abnormal liver function, abnormal lung function, abnormal neurological function, abnormal gastrointestinal function, etc. All of these are caused by the deposition of amyloid substances and are, therefore, called amyloidosis. There are dozens of amyloid substances, and the amyloidosis caused by this monoclonal light chain amyloid substance is collectively called primary amyloidosis. Can this disease be fatal? How long does it usually survive after its onset? From the causes of amyloidosis, we already know that amyloidosis damages the vital organs of the body, kidney, heart, liver, lung, gastrointestinal tract, and nerves, and problems in any one organ can be fatal, not to mention that several organs may have problems at the same time, so it is a very fatal disease. Generally speaking, amyloid deposition in organs occurs slowly and accumulates gradually, and when the accumulation reaches a certain amount, the organs cannot maintain normal function, and the patient will show various manifestations, which may be detected and diagnosed in the hospital. In fact, when a patient is diagnosed with amyloidosis, many organs are already severely damaged, so most patients can only survive for 2-3 years after diagnosis without treatment; if the heart is significantly damaged at the time of diagnosis, they can usually only survive for about six months. Why do you get this disease? Do different causes of the disease bring the same harm? As with many malignant diseases, the cause is not yet known. We just mentioned that there are dozens of amyloid substances, all of which can cause multiple organ damage just like primary amyloidosis caused by monoclonal light chains, only the different types of preferences damage different organs.