There are certain surgical indications for undergoing bypass surgery, which has become the main treatment for coronary artery disease since the world’s first use of coronary artery bypass grafting for coronary artery disease began in 1967. Its immediate and long-term results have been confirmed by a large number of cases and long follow-ups worldwide. The main principle of bypass surgery is to maximize myocardial ischemia and reduce the risk to the patient. The main indications for coronary artery bypass surgery are: (1) left main stem lesions with stenosis greater than 50%. (2) Bypass surgery should be selected for lesions equivalent to left main stem lesions, i.e., significant stenosis (≥70% or more) in the proximal segment of the left anterior descending branch and the proximal segment of the left circumflex branch. (3) Two or more vascular lesions in combination with diabetes, especially two vascular lesions with stenosis of the proximal segment of the anterior descending branch. (4) Diffuse lesions of three or more vessels with hypoplastic left heart should undergo bypass surgery. (5) Single vessel lesions especially long segment lesions of the anterior descending branch or proximal segment of the right coronary artery. (6) Acute myocardial infarction with cardiogenic shock. (7) Combined cardiac mechanical complications requiring surgical treatment such as tendon rupture mitral regurgitation, septal perforation or combined ventricular wall tumors. (8) Stable angina pectoris with ineffective medical treatment, unstable angina pectoris; post-infarction angina pectoris; myocardial infarction without Q waves. (9) Those who have failed partial intervention or have acute complications of rib, such as severe coronary injury. (10) Recurrence of angina after bypass surgery and bypass surgery again. In conclusion: the basic indications for bypass surgery are patients whose symptoms of myocardial ischemia are not controlled by medical treatment, and generally speaking, the greater the extent of ischemia and the more severe the stenosis, the better the bypass effect. If the coronary artery lesion is diffuse distal coronary artery can not be bypass surgery, serious cardiopulmonary, hepatic and renal insufficiency can not tolerate surgical trauma blow is a contraindication to surgery.