How does pressure-monitored catheter ablation for atrial fibrillation work?

  Recently, a team led by Professor Li Yigang from the Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, successfully carried out the first case of atrial fibrillation (AF) treated with pressure-monitored ablation catheter in East China, and the safety and efficacy of RF ablation treatment for AF has been further enhanced by the introduction of the new catheter into the clinic.  Atrial fibrillation is a common clinical arrhythmia, the incidence of which increases with age, with a statistical incidence of 4% in people over 60 years of age and up to 10% in people over 75 years of age. The main risk of the disease is stroke, and studies have shown non-valvularity.  The incidence of stroke in patients with atrial fibrillation is 5.6 times higher than normal, and the incidence of stroke in valvular atrial fibrillation is 17.6 times higher than normal. Stroke caused by atrial fibrillation has a disability rate of about 25% and a mortality rate of up to 25%, which not only brings great suffering to patients and families, but also imposes a heavy economic burden on society. Restoring and maintaining sinus rhythm is of great importance to patients, however, for most patients, the role of drug diverter to maintain sinus rhythm is often very limited, and radiofrequency catheter ablation of atrial fibrillation has been widely performed in recent years. It has become the preferred first-line treatment strategy for paroxysmal atrial fibrillation in treatment guidelines, including those in Europe and the United States.  The patient was a 75-year-old patient with recurrent episodes of atrial fibrillation, with palpitations and chest tightness and sweating with each episode. After the treatment team’s study and discussion, radiofrequency ablation was recommended. In view of the patient’s advanced age of 75, the safety and effectiveness of the procedure were particularly important, and it was decided to use a new type of pressure monitoring catheter to perform the procedure.  Professor Li Yigang said that there is now a consensus in the electrophysiology community on the ablation procedure for atrial fibrillation, which is based on the electrical isolation of the circumferential pulmonary vein with additional stepwise left atrial linear ablation or fracture potential ablation as needed by the patient’s condition. Continuous and transmural injury to the atrial wall is required to achieve permanent pulmonary vein isolation and effective linear or fracture potential ablation. The decision of wall penetration and adequacy of the ablation site depends primarily on the catheter apposition to the target tissue (atrial wall), in addition to ablation power and time. The intermittent rate of ablation decreases significantly with the increase of the ablation force, and there is almost no intermittent ablation when the ablation force reaches 20g (the intermittent rate is only 3%), and there is no intermittent ablation at all when the ablation force reaches 30g.  As a minimally invasive treatment, its effectiveness and safety are the common concern of both patients and doctors. Effective ablation catheter contact with the atrial wall during the procedure is a major factor in achieving efficacy and ensuring safety. If the catheter is not in contact with the atrium, the ablation will be impermeable and the probability of recurrence will increase after the procedure; if the catheter is too strong, the ablation will be excessive and the extracardiac tissues will be injured, leading to cardiac perforation and pericardial compression, which will endanger the life and increase the risk of the procedure. Therefore, the appropriate docking force is a reliable indicator of successful ablation without complications. To achieve an effective and safe catheter apposition, on the one hand, the operator needs to learn from the experience of his predecessors and on the other hand, he needs to accumulate positive and negative experience and gradually develop a good handedness. In addition, the continuous improvement of surgical instruments also helps the surgeon to better control the safety of surgery. A new type of pressure monitoring catheter is such a catheter. The new pressure marking catheter can directly measure the force and direction of the catheter tip against the target tissue and display the measured value in real time (as shown in the figure). The results of clinical studies with this catheter have shown it to be useful in the ablation of atrial fibrillation.  With the current availability and application of pressure monitoring catheters, real-time monitoring of catheter-to-tissue contact force has become possible. It significantly improves the safety of catheterization while increasing the effectiveness of ablation. We have reason to believe that in the near future, radiofrequency ablation therapy for atrial fibrillation will take a new step forward and individualize the ablation protocol for different patients, so that more patients with atrial fibrillation can benefit from it.