Dust mites are the most prevalent allergens worldwide. It is the most important cause of common allergic diseases such as allergic rhinitis, allergic asthma, chronic cough and urticaria. Mites in mattress stuffing are an important source of indoor allergens, and house dust mites are also found in excessively fluffy furniture, carpets and pillows. House dust mites feed on shed human epithelium and reach seasonal peak concentrations in September and October. The allergenicity of mites does not vary by mite species. Specific mite allergens have been identified and isolated (Der p 1 and Der p 2 of D. pteronyssinus; Der f 1 and Der f 2 of D. farinae). der p 1 is considered to be the most immunodominant house dust mite allergen. It has a cysteine protease activity that plays a major role for its allergenicity. Protein hydrolase activity disrupts the tight junctions between epithelial cells and contributes to the entry of allergens into the epithelium and also promotes the differentiation of CD23 and CD25, including the synthesis of IgE. The highest allergen concentrations are found in mite feces, but some studies have shown that a variety of other particles can also carry mite allergens. Therefore, preventive measures include not only mite eradication, but also physical transfer of mites, or the creation of barriers between mite allergens and suspected allergic individuals. Studies have shown that effective mite eradication is of significant clinical value. Because dust particles carrying mite allergens are larger than those carrying cat allergens, they settle faster, so patients generally exhibit mild allergy symptoms only after longer exposure to mite allergens. When vacuuming or cleaning carpets, beds, and upholstery, patients may experience acute allergies such as sneezing, runny nose, cough, allergic asthma, or a generalized wind rash due to short-term exposure to high levels of mite allergens.