Urticaria, commonly known as “rubella”, is a limited edema that occurs in the skin and mucous membranes due to a temporary increase in vascular permeability. Urticaria accompanied by fever may be associated with infections or systemic diseases, etc. While treating urticaria, it is also necessary to identify the cause of the disease and carry out symptomatic treatment. Infection is one of the triggers of urticaria, if accompanied by fever may be related to infections, such as hepatitis virus, streptococcus, fungi, coxsackie virus, parasites and so on. It is necessary to identify the cause of the disease according to different pathogens, choose the appropriate drugs for anti-infection treatment, while oral antihistamine drugs such as loratadine. Malignant tumors, systemic lupus erythematosus and other diseases can also induce urticaria with fever, should be identified after the primary disease and actively treat the primary disease, and comply with the doctor’s instructions oral antihistamine drugs such as loratadine. Urticaria with fever causes more reasons, should be timely consultation, identify the cause of the disease under the guidance of the doctor standardized treatment.